A single dose of psilocybin induces lasting changes in metabolic connectivity within biologically informed rat brain networks related to compulsions and anxiety.

Published: May 28, 2024

Serotonergic psychedelic drugs have shown promising benefits in trials for various neuropsychiatric disorders. While the acute effects of these psychedelics last only a few hours, positive therapeutic can persist long after single administration. produce their by activating serotonin 2A receptors, but they differ other pharmacological aspects. To guide safest and most effective treatment specific disorders, it is crucial to gain better understanding distinct long-term on living brain. Here we demonstrate how three different serotonergic psychedelics; psilocybin, LSD 2C-B, induce patterns rat brain metabolic activity connectivity. The doses administered were chosen reflect humans. We found that, psilocybin induced pattern effects, particularly focusing changes connectivity between cortical regions such as orbitofrontal, medial prefrontal, insula cortex, well with dorsal striatum, thalamus, hippocampus. In contrast, 2C-B showed more similar impacts centered inhibition anterior cingulate cortex. This was accompanied increased amygdala hypothalamus, along heightened dopamine cell-rich ventral tegmental area substantia nigra. Our findings within networks provide new insights into shared drug-selective mechanisms underlying substances These could offer guidance which might be beneficial certain psychiatric diseases.

Language: Английский

Licit use of illicit drugs for treating depression: the pill and the process

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(12)

Published: June 16, 2024

Psilocybin, MDMA, and ketamine have emerged as potentially effective treatments for rapid amelioration of the symptoms mood related psychiatric disorders. All clinical data collected so far with regard to psilocybin or which reported positive outcomes treating depression, anxiety, posttraumatic stress disorder, drug alcohol use disorders, involved clinician-assisted intervention. While case is assumed be different, first report successful in psychiatry depression was combination psychotherapy, an emerging literature suggests that subjective state individual experiences predicts outcome. This Review will focus on (a) a brief review literature, showing context process administration has been integrative component published work; (b) importance trials compare efficacy ("pill") stand-alone treatment versus psychological support ("process"); (c) suggestions future approaches animal models take into account role systems behavioral neuroscience explaining potential context, experience, expectancy effect.

Language: Английский