Microbiota and Resveratrol: How Are They Linked to Osteoporosis? DOI Creative Commons
C. Meyer, Aranka Brockmueller, Vicenç Ruiz de Porras

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1145 - 1145

Published: July 3, 2024

Osteoporosis (OP), which is characterized by a decrease in bone density and increased susceptibility to fractures, closely linked the gut microbiota (GM). It increasingly realized that GM plays key role maintenance of functioning multiple organs, including bone, producing bioactive metabolites such as short-chain fatty acids (SCFA). Consequently, imbalances GM, referred dysbiosis, have been identified with significant reduction beneficial metabolites, decreased SCFA associated chronic inflammatory processes, activation NF-κB at epigenetic level, recognized main cause many diseases, OP. Furthermore, regular or long-term medications antibiotics non-antibiotics proton pump inhibitors, chemotherapy, NSAIDs, found contribute development highlighting an urgent need for new treatment approaches. A promising preventive adjuvant approach combat dysbiosis natural polyphenols resveratrol, prebiotic functions ensure optimal microenvironment GM. Resveratrol offers range benefits, anti-inflammatory, anti-oxidant, analgesic, effects. In particular, has shown convert into highly metabolically active molecules even more potent properties, supporting synergistic polyphenol–GM axis. This review addresses question how can enhance effects resveratrol modulator, promote growth diversity thus providing important insights prevention co-treatment

Language: Английский

Microbiota and Resveratrol: How Are They Linked to Osteoporosis? DOI Creative Commons
C. Meyer, Aranka Brockmueller, Vicenç Ruiz de Porras

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1145 - 1145

Published: July 3, 2024

Osteoporosis (OP), which is characterized by a decrease in bone density and increased susceptibility to fractures, closely linked the gut microbiota (GM). It increasingly realized that GM plays key role maintenance of functioning multiple organs, including bone, producing bioactive metabolites such as short-chain fatty acids (SCFA). Consequently, imbalances GM, referred dysbiosis, have been identified with significant reduction beneficial metabolites, decreased SCFA associated chronic inflammatory processes, activation NF-κB at epigenetic level, recognized main cause many diseases, OP. Furthermore, regular or long-term medications antibiotics non-antibiotics proton pump inhibitors, chemotherapy, NSAIDs, found contribute development highlighting an urgent need for new treatment approaches. A promising preventive adjuvant approach combat dysbiosis natural polyphenols resveratrol, prebiotic functions ensure optimal microenvironment GM. Resveratrol offers range benefits, anti-inflammatory, anti-oxidant, analgesic, effects. In particular, has shown convert into highly metabolically active molecules even more potent properties, supporting synergistic polyphenol–GM axis. This review addresses question how can enhance effects resveratrol modulator, promote growth diversity thus providing important insights prevention co-treatment

Language: Английский

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