Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1 DOI Creative Commons
Sijie Yang, Yuanling Yu, Fanchong Jian

et al.

Emerging Microbes & Infections, Journal Year: 2024, Volume and Issue: 13(1)

Published: April 15, 2024

The recent emergence of a SARS-CoV-2 saltation variant, BA.2.87.1, which features 65 spike mutations relative to BA.2, has attracted worldwide attention. In this study, we elucidate the antigenic characteristics and immune evasion capability BA.2.87.1. Our findings reveal that BA.2.87.1 is more susceptible XBB-induced humoral immunity compared JN.1. Notably, lacks critical escaping in receptor binding domain (RBD) thus allowing various classes neutralizing antibodies (NAbs) were escaped by XBB or BA.2.86 subvariants neutralize although deletions N-terminal (NTD), specifically 15-23del 136-146del, compensate for resistance immunity. Interestingly, several antibody drugs have been found restore their efficacy against including SA58, REGN-10933 COV2-2196. Hence, our results suggest may not become widespread until it acquires multiple RBD achieve sufficient comparable

Language: Английский

Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1 DOI Creative Commons
Sijie Yang, Yuanling Yu, Fanchong Jian

et al.

Emerging Microbes & Infections, Journal Year: 2024, Volume and Issue: 13(1)

Published: April 15, 2024

The recent emergence of a SARS-CoV-2 saltation variant, BA.2.87.1, which features 65 spike mutations relative to BA.2, has attracted worldwide attention. In this study, we elucidate the antigenic characteristics and immune evasion capability BA.2.87.1. Our findings reveal that BA.2.87.1 is more susceptible XBB-induced humoral immunity compared JN.1. Notably, lacks critical escaping in receptor binding domain (RBD) thus allowing various classes neutralizing antibodies (NAbs) were escaped by XBB or BA.2.86 subvariants neutralize although deletions N-terminal (NTD), specifically 15-23del 136-146del, compensate for resistance immunity. Interestingly, several antibody drugs have been found restore their efficacy against including SA58, REGN-10933 COV2-2196. Hence, our results suggest may not become widespread until it acquires multiple RBD achieve sufficient comparable

Language: Английский

Citations

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