Changes in intra- and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats DOI Creative Commons

Stephen Mari,

Charly G. Lecomte,

Angèle N. Merlet

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

In quadrupeds, such as cats, cutaneous afferents from the forepaw dorsum signal external perturbations and send signals to spinal circuits coordinate activity in muscles of all four limbs. How these reflex pathways forelimb are reorganized after an incomplete cord injury is not clear. Using a staggered thoracic lateral hemisections paradigm, we investigated changes intralimb interlimb by electrically stimulating left right superficial radial nerves seven adult cats recording responses five ten hindlimb muscles. After first (right T5-T6) second (left T10-T11) hemisections, forelimb-hindlimb coordination was altered weakened. hemisection, required balance assistance perform quadrupedal locomotion. Short-, mid- long-latency homonymous crossed their phase modulation remained largely unaffected hemisections. The occurrence homolateral diagonal evoked with nerve stimulation significantly reduced at time point but partially recovered stimulation. These were lost or hemisection. When present, responses, including diagonal, maintained phase-dependent modulation. Therefore, our results show considerable loss transmission cervical lumbar levels injury, albeit preservation modulation, likely affecting functional perturbations.

Language: Английский

Changes in intra- and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats DOI Creative Commons

Stephen Mari,

Charly G. Lecomte,

Angèle N. Merlet

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

In quadrupeds, such as cats, cutaneous afferents from the forepaw dorsum signal external perturbations and send signals to spinal circuits coordinate activity in muscles of all four limbs. How these reflex pathways forelimb are reorganized after an incomplete cord injury is not clear. Using a staggered thoracic lateral hemisections paradigm, we investigated changes intralimb interlimb by electrically stimulating left right superficial radial nerves seven adult cats recording responses five ten hindlimb muscles. After first (right T5-T6) second (left T10-T11) hemisections, forelimb-hindlimb coordination was altered weakened. hemisection, required balance assistance perform quadrupedal locomotion. Short-, mid- long-latency homonymous crossed their phase modulation remained largely unaffected hemisections. The occurrence homolateral diagonal evoked with nerve stimulation significantly reduced at time point but partially recovered stimulation. These were lost or hemisection. When present, responses, including diagonal, maintained phase-dependent modulation. Therefore, our results show considerable loss transmission cervical lumbar levels injury, albeit preservation modulation, likely affecting functional perturbations.

Language: Английский

Citations

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