bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 4, 2024
Abstract Variation in transmission plays a crucial role shaping the dynamics of infectious diseases. Population heterogeneity is known to contribute this variation and often represented epidemiological models. However, it not always clear priori what sources should meaningfully given scenario, can be challenging infer distributions underlying processes from data. In study, we demonstrate use Caenorhabditis elegans as tractable system which high-quality data produced for experimental epidemics. We show that shedding susceptibility host experimentally decoupled measure processes. observe quantify super-shedding heterogeneous susceptibility, population outcomes have features conserved with real-world Our results bacterial small model organism establish C. promising quantitative
Language: Английский