Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function
Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(41)
Published: Oct. 4, 2024
Systems
consolidation
is
a
common
feature
of
learning
and
memory
systems,
in
which
long-term
initially
stored
one
brain
region
becomes
persistently
another
region.
We
studied
the
dynamics
systems
simple
circuit
architectures
with
two
sites
plasticity,
an
early-learning
late-learning
area.
show
that
synaptic
during
analog
can
be
understood
as
temporal
integration
process,
by
transient
changes
activity
driven
plasticity
area
are
accumulated
into
persistent
at
site.
This
principle
naturally
leads
to
speed-accuracy
tradeoff
provides
insight
how
mitigates
stability-plasticity
dilemma
storing
new
memories
while
preserving
core
features
older
ones.
Furthermore,
it
imposes
constraints
on
circuit.
First,
rule
site
must
stably
support
continuum
possible
outputs
for
given
input.
this
readily
achieved
heterosynaptic
but
not
standard
Hebbian
rules.
Second,
turn
off
process
prevent
erroneous
site,
neural
reset
its
baseline
activity.
provide
biologically
plausible
implementations
propose
functional
roles
stabilizing
elements
cerebellar
Language: Английский
Behavioral state regulates the dynamics of memory consolidation
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
ABSTRACT
Long-term
memories
are
consolidated
over
time,
progressively
becoming
more
stable
and
resistant
to
interference.
Memory
consolidation
occurs
offline
often
involves
transfer
of
from
one
brain
site
another.
For
many
motor
memories,
is
thought
involve
early
learning
in
cerebellar
cortex
that
subsequently
transferred
the
nuclei.
Here
we
report
mice,
engaging
locomotor
activity
during
training
a
classical
conditioning
task
shifts
critical
time
window
for
memory
consolidation,
just
after
sessions,
between
trials,
within
sessions.
This
temporal
shift
requires
natural
patterns
granule
cell
intertrial
intervals
accompanied
by
earlier
involvement
downstream
nucleus.
These
results
reveal
can
be
surprisingly
brief,
on
timescale
seconds
minutes,
it
dynamically
regulated
behavioral
state.
Language: Английский