bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 13, 2024
Understanding the neural basis of fear expression in rodents has implications for understanding pathological responses that characterize posttraumatic stress disorder. Even though disorder is more common females, little known about circuit interactions supporting female rodents. In this study, we were interested determining whether activity associated with contextual differed between males and females within projections from medial prefrontal cortex to ventrolateral periaqueductal gray, neurons do not project gray. We infused a viral retrograde tracer into gray male rats trained them conditioning task. The following day re-exposed context sacrificed shortly thereafter. Neural was measured using EGR1 immunofluorescence. behavioral results showed exhibited higher levels freezing during test than females. Male underwent training testing an increase proportion infected cells express PL compared had only received exposure. Trained different controls, however direct comparison sexes different. labeled by tracer, fear-induced prelimbic Conversely, infralimbic as males. These suggest sex differences may involve relative cortex.
Language: Английский