Skeletal muscle hypertrophy: cell growth is cell growth

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 327(3), P. C614 - C618

Published: July 29, 2024

Roberts et al. have provided an insightful counterpoint to our review article on the utility of synergist ablation model. The purpose this is provide some further dialogue regarding strengths and weaknesses Specifically, we highlight that robustness model overshadows surgical limitations. We also compare transcriptomic responses in mice resistance exercise humans identify common pathways. conclude "cell growth cell growth" mechanisms available cells accumulate biomass increase size are similar across types independent rate growth.

Language: Английский

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Transcriptional Analysis of Cancer Cachexia: Conserved and Unique Features Across Pre-Clinical Models and Biological Sex

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 327(6), P. C1514 - C1531

Published: Oct. 28, 2024

This study is among the first to integrate and compare skeletal muscle transcriptional landscape across multiple preclinical models biological sexes. We highlight that 1) early CC changes are two-thirds conserved at late stages, 2) DEGs largely model sex specific, 3) factors including CLOCK ARNTL/BMAL1, which influence gene expression, might represent a global therapeutic target with chance of efficacy various cancer types.

Language: Английский

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Resistance but not endurance training suppresses glucocorticoid-induced leucine zipper (GILZ) expression in human skeletal muscle

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

ABSTRACT The glucocorticoid-induced leucine zipper (GILZ) serves as an anti-inflammatory regulator of gene expression in different tissues and is also expressed human skeletal muscle. GILZ mediates the anti-myogenic myotoxic side effects statins via a shift Akt/FoxO signaling pathways. Recent evidence suggests that suppression regulated by physical exercise, with external load being decisive factor. Interestingly, statin treatment rarely tolerated habitually exercising individuals due to statin-associated muscle symptoms (SAMS). opposing regulation underpins this detrimental interaction key measures cardiovascular prevention. This hypothetically differs between diverging exercise modalities mechanosensitive manner. To verify emerging evidence, we conducted systematic search Gene Expression Omnibus (GEO) repository for studies reporting acute either endurance (END), conventional resistance (RT), or eccentric training (ECC). 15 204 participants (22 females; 182 males, 18 90 years age) were included analysis. Participants’ activity levels ranged from sedentary trained. RT resulted highest suppression, significantly differing expressional change after END (-0.46 ± 1.11 vs. -0.07 1.08; p = 0.03), but not ECC -0.46 0.95; 0.19). Furthermore, subgrouping revealed RT-experienced exhibited more pronounced than their inexperienced counterparts (-0.98 0.66 -0.34 1.16; 0.001). Our results strengthen assumption mechanical loading can be considered mediator exercise-induced changes expression.

Language: Английский

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Resistance but not endurance training suppresses glucocorticoid-induced leucine zipper (GILZ) expression in human skeletal muscle

European Journal of Applied Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Language: Английский

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