Sex-specific epigenetic signatures of circulating urate and its increase after BCG vaccination
Abstract
Background:
Urate
concentration
and
the
physiological
regulation
of
urate
homeostasis
exhibit
clear
sex
differences.
DNA
methylation
has
been
shown
to
explain
a
substantial
proportion
serum
variance,
mediate
genetic
effect
on
concentration,
co-regulate
with
cardiometabolic
traits.
However,
whether
is
associated
in
sex-dependent
manner
unknown.
Additionally,
it
worth
investigating
if
changes
after
perturbations,
such
as
vaccination,
are
sex-specific
manner.
Methods:
We
investigated
association
between
concentrations
Dutch
cohort
325
healthy
individuals.
were
measured
before
Bacillus
Calmette-Guérin
(BCG)
used
perturbation
increased
gout
flares.
The
analysis
included
united,
interaction,
sex-stratified
analysis.
Validation
identified
CpG
sites
was
conducted
using
three
independent
cohorts.
Results:
215
males,
while
5
females,
indicating
associations.
Circulating
significantly
BCG
baseline
differences
vaccination
males
enriched
neuro-protection
pathways,
whereas
change-associated
related
lipid
glucose
metabolism.
Conclusion:
Our
study
enhances
understanding
how
epigenetic
factors
contribute
regulating
levels
These
insights
have
significant
implications
for
diagnosis,
prevention,
treatment
various
urate-related
diseases
highlight
importance
personalized
approaches
medicine.
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: July 22, 2024
Language: Английский