Oxytocin and Dopamine Receptor Expression: Cellular Level Implications for Pair Bonding DOI Creative Commons

Meredith K. Loth,

J Schmidt,

Cassandra A. Gonzalez

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Oxytocin ( Oxtr ) and dopamine Drd1 , Drd2 receptors provide a canonical example for how differences in neuromodulatory drive individual species-level behavioral variation. These systems exhibit striking functionally-relevant nucleus accumbens (NAc) expression across monogamous prairie voles Microtus ochrogaster promiscuous meadow pennsylvanicus ). However, their cellular organization remains largely unknown. Using multiplex situ hybridization, we mapped sexually naïve mate-paired voles. Prairie have more Oxtr+ cells than voles, but distribution dopamine-receptor cell class was similar, indicating general upregulation rather bias. enriched that express both Drd1+/Drd2+ suggesting these may be particularly sensitive to oxytocin. We found no species or pairing-induced Drd1+ Drd2+ counts, prior reports of reflect already expressing receptors. Finally, used single-nucleus sequencing the first comprehensive map Drd1-5 molecularly-defined NAc types vole. results critical framework understanding nonapeptide catecholamine recruit distinct shape social behavior.

Language: Английский

Brain gene expression syncs between bonded prairie voles DOI
Shaena Montanari

The Transmitter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Oxytocin and Dopamine Receptor Expression: Cellular Level Implications for Pair Bonding DOI Creative Commons

Meredith K. Loth,

J Schmidt,

Cassandra A. Gonzalez

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Oxytocin ( Oxtr ) and dopamine Drd1 , Drd2 receptors provide a canonical example for how differences in neuromodulatory drive individual species-level behavioral variation. These systems exhibit striking functionally-relevant nucleus accumbens (NAc) expression across monogamous prairie voles Microtus ochrogaster promiscuous meadow pennsylvanicus ). However, their cellular organization remains largely unknown. Using multiplex situ hybridization, we mapped sexually naïve mate-paired voles. Prairie have more Oxtr+ cells than voles, but distribution dopamine-receptor cell class was similar, indicating general upregulation rather bias. enriched that express both Drd1+/Drd2+ suggesting these may be particularly sensitive to oxytocin. We found no species or pairing-induced Drd1+ Drd2+ counts, prior reports of reflect already expressing receptors. Finally, used single-nucleus sequencing the first comprehensive map Drd1-5 molecularly-defined NAc types vole. results critical framework understanding nonapeptide catecholamine recruit distinct shape social behavior.

Language: Английский

Citations

0