Interhemispheric CA1 projections support spatial cognition and are affected in a mouse model of the 22q11.2 deletion syndrome DOI Creative Commons
Noelia S. de León-Reyes, Maria Helena Bortolozzo-Gleich, Yuki Nomura

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Untangling the hippocampus connectivity is critical for understanding mechanisms supporting learning and memory. However, function of interhemispheric connections between hippocampal formations still poorly understood. So far, two major commissural projections have been characterized in rodents. Mossy cells from hilus dentate gyrus project to inner molecular layer contralateral CA3 CA2 pyramidal neuron axonal collaterals CA3, CA1. In contrary, little known about projection CA1 region. Here, we show that neurons dorsal as well subiculum. We further demonstrate subiculum supports spatial memory working WT mice, cognitive functions impaired male mice

Language: Английский

Connectivity takes U-turn in people with rare autism-linked mutations DOI
Holly E. Barker

The Transmitter, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Interhemispheric CA1 projections support spatial cognition and are affected in a mouse model of the 22q11.2 deletion syndrome DOI Creative Commons
Noelia S. de León-Reyes, Maria Helena Bortolozzo-Gleich, Yuki Nomura

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Untangling the hippocampus connectivity is critical for understanding mechanisms supporting learning and memory. However, function of interhemispheric connections between hippocampal formations still poorly understood. So far, two major commissural projections have been characterized in rodents. Mossy cells from hilus dentate gyrus project to inner molecular layer contralateral CA3 CA2 pyramidal neuron axonal collaterals CA3, CA1. In contrary, little known about projection CA1 region. Here, we show that neurons dorsal as well subiculum. We further demonstrate subiculum supports spatial memory working WT mice, cognitive functions impaired male mice

Language: Английский

Citations

0