Epigenomic heterogeneity as a source of tumour evolution
Nature reviews. Cancer,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
Language: Английский
Deciphering the Complexities of Adult Human Steady State and Stress-Induced Hematopoiesis: Progress and Challenges
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 671 - 671
Published: Jan. 14, 2025
Human
hematopoietic
stem
cells
(HSCs)
have
traditionally
been
viewed
as
self-renewing,
multipotent
with
enormous
potential
in
sustaining
essential
steady
state
blood
and
immune
cell
production
throughout
life.
Indeed,
around
86%
(1011-1012)
of
new
generated
daily
a
healthy
young
human
adult
are
origin.
Therapeutically,
HSCs
contributed
to
over
1.5
million
transplants
(HCTs)
globally,
making
this
the
most
successful
regenerative
therapy
date.
We
will
commence
review
by
briefly
highlighting
selected
key
achievements
(from
1868
end
20th
century)
that
accomplishment.
Much
our
knowledge
hematopoiesis
is
based
on
small
animal
models
that,
despite
their
importance,
do
not
always
recapitulate
hematopoiesis.
Given
this,
we
critically
progress
challenges
faced
identifying
tracing
lineage
differentiation
trajectories,
referring
murine
studies
needed.
Moving
forward
given
dynamic
can
readily
adjust
variety
stressors,
then
discuss
recent
research
advances
contributing
understanding
(i)
which
HSPCs
maintain
hematopoiesis,
(ii)
where
these
located,
(iii)
mechanisms
come
into
play
when
homeostatic
switches
stress-induced
or
emergency
Language: Английский
Stem Cells in Regenerative Medicine: Unlocking Therapeutic Potential Through Stem Cell Therapy, 3D Bioprinting, Gene Editing, and Drug Discovery
Biomedical Engineering Advances,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100172 - 100172
Published: May 1, 2025
Language: Английский
New frameworks for hematopoiesis derived from single-cell genomics
Blood,
Journal Year:
2024,
Volume and Issue:
144(10), P. 1039 - 1047
Published: July 10, 2024
Language: Английский
Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks
Open Biology,
Journal Year:
2024,
Volume and Issue:
14(10)
Published: Oct. 1, 2024
Sex-specific
differences
in
lifespan
and
ageing
are
observed
various
species.
In
humans,
women
generally
live
longer
but
frailer
suffer
from
different
age-related
diseases
compared
to
men.
The
hallmarks
of
ageing,
such
as
genomic
instability,
telomere
attrition
or
loss
proteostasis,
exhibit
sex-specific
patterns.
Sex
chromosomes
sex
hormones,
well
the
epigenetic
regulation
inactive
X
chromosome,
have
been
shown
affect
diseases.
Here
we
review
current
knowledge
on
biological
basis
sex-biased
ageing.
While
our
is
focused
also
discuss
examples
model
organisms
mouse,
fruit
fly
killifish.
Understanding
these
molecular
crucial
elderly
population
expected
double
worldwide
by
2050,
making
approaches
diagnosis,
treatment,
therapeutic
development
prevention
a
pressing
need.
Language: Английский
EpiCHAOS: a metric to quantify epigenomic heterogeneity in single-cell data
Genome biology,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Dec. 2, 2024
Abstract
Epigenetic
heterogeneity
is
a
fundamental
property
of
biological
systems
and
recognized
as
potential
driver
tumor
plasticity
therapy
resistance.
Single-cell
epigenomics
technologies
have
been
widely
employed
to
study
epigenetic
variation
between—but
not
within—cellular
clusters.
We
introduce
epiCHAOS:
quantitative
metric
cell-to-cell
heterogeneity,
applicable
any
single-cell
data
type.
After
validation
in
synthetic
datasets,
we
apply
epiCHAOS
investigate
global
region-specific
patterns
across
diverse
systems.
EpiCHAOS
provides
an
excellent
approximation
stemness
development
malignancy,
making
it
valuable
addition
cancer
analyses.
Language: Английский
EpiCHAOS: a metric to quantify epigenomic heterogeneity in single-cell data
Published: April 28, 2024
Abstract
Epigenetic
heterogeneity
is
a
fundamental
property
of
biological
systems,
and
recognized
as
potential
driver
tumor
plasticity
therapy
resistance.
Single-cell
epigenomics
technologies
have
been
widely
employed
to
study
epigenetic
variation
between
–
but
not
within
cellular
clusters.
We
introduce
epiCHAOS:
quantitative
metric
cell-to-cell
heterogeneity,
applicable
any
single-cell
data
type.
After
validation
in
synthetic
datasets,
we
applied
epiCHAOS
investigate
global
region-specific
patterns
across
diverse
systems.
EpiCHAOS
provides
an
excellent
approximation
stemness
development
malignancy,
making
it
valuable
addition
cancer
analyses.
Language: Английский
Nongenetic evolution of the tumor: from challenges to new therapeutic opportunities
Molecular Oncology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 18, 2024
The
ability
of
cancer
cells
to
change
and
adapt
poses
a
critical
challenge
identifying
curative
solutions.
Tumor
evolution
has
been
extensively
studied
from
genetic
perspective,
guide
clinicians
in
selecting
the
most
appropriate
therapeutic
option
based
on
patient's
mutational
profile.
However,
several
studies
reported
that
tumors
can
evolve
toward
more
aggressive
stages
or
become
resistant
therapies
without
changing
their
makeup.
Indeed,
cell‐intrinsic
cell‐extrinsic
mechanisms
contribute
tumor
evolution.
In
this
viewpoint,
I
focus
how
chromatin,
epigenetic,
transcriptional
changes
evolution,
allowing
transition
different
cell
states
bypass
response
therapies.
Although
nongenetic
is
harder
trace
predict,
understanding
its
principles
might
open
new
opportunities.
Language: Английский