The porcine skin microbiome exhibits broad fungal antagonism DOI Creative Commons

Karinda F. De La Cruz,

Elizabeth C. Townsend, Jonathan Cheong

et al.

Fungal Genetics and Biology, Journal Year: 2024, Volume and Issue: 173, P. 103898 - 103898

Published: May 28, 2024

The skin and its microbiome function to protect the host from pathogen colonization environmental stressors. In this study, using Wisconsin Miniature Swine™ model, we characterize porcine fungal bacterial microbiomes, identify isolates displaying antifungal activity, use whole-genome sequencing biosynthetic gene clusters encoding for secondary metabolites that may be responsible antagonistic effects on fungi. Through comprehensive approach of paired with culturomics, report discovery novel species Corynebacterium Rothia. Further, study represents first evaluation mycobiome bacterial-fungal interactions surface. Several diverse exhibit potent properties against opportunistic pathogens in vitro. Genomic analysis inhibitory revealed a repertoire uncharacterized suggesting reservoir chemical biological diversity. Collectively, potential unique source antifungals.

Language: Английский

The porcine skin microbiome exhibits broad fungal antagonism DOI Creative Commons

Karinda F. De La Cruz,

Elizabeth C. Townsend, Jonathan Cheong

et al.

Fungal Genetics and Biology, Journal Year: 2024, Volume and Issue: 173, P. 103898 - 103898

Published: May 28, 2024

The skin and its microbiome function to protect the host from pathogen colonization environmental stressors. In this study, using Wisconsin Miniature Swine™ model, we characterize porcine fungal bacterial microbiomes, identify isolates displaying antifungal activity, use whole-genome sequencing biosynthetic gene clusters encoding for secondary metabolites that may be responsible antagonistic effects on fungi. Through comprehensive approach of paired with culturomics, report discovery novel species Corynebacterium Rothia. Further, study represents first evaluation mycobiome bacterial-fungal interactions surface. Several diverse exhibit potent properties against opportunistic pathogens in vitro. Genomic analysis inhibitory revealed a repertoire uncharacterized suggesting reservoir chemical biological diversity. Collectively, potential unique source antifungals.

Language: Английский

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