PRDM16-DT is a Brain and Astrocyte-Specific lncRNA Implicated in Alzheimers Disease DOI
Sophie Schröder,

Ulrike Fuchs,

Verena Gisa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Abstract Astrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic maintenance, and neurotransmitter recycling. Under pathological conditions, deregulation of astrocytes contributes neurodegenerative diseases such as Alzheimer’s disease (AD), highlighting the growing interest in targeting astrocyte function address early phases AD pathogenesis. While most research this field has focused on protein-coding genes, non-coding RNAs, particularly long RNAs (lncRNAs), have emerged significant regulatory molecules. In study, we identified lncRNA PRDM16-DT highly enriched human brain, where it is almost exclusively expressed astrocytes. its murine homolog, Prdm16os , are downregulated brains patients models. line with this, knockdown revealed critical role maintaining homeostasis supporting neuronal by regulating genes essential glutamate uptake, lactate release, spine density through interactions RE1-Silencing Transcription factor (Rest) Polycomb Repressive Complex 2 (PRC2). Notably, CRISPR-mediated overexpression mitigated functional deficits induced stimuli linked These findings underscore importance potential a novel therapeutic target disorders characterized dysfunction

Language: Английский

Exosomes in Regulating miRNAs for Biomarkers of Neurodegenerative Disorders DOI
Azhagu Madhavan Sivalingam,

Darshitha D Sureshkumar

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

1
Exploring the Role of microRNAs as Blood Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia DOI Open Access
Irene Petracci, Sonia Bellini, Katarzyna Goljanek‐Whysall

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3399 - 3399

Published: April 5, 2025

Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common forms of globally. AD is characterized by accumulation amyloid-β (Aβ) plaques hyperphosphorylated tau in brain, leading to progressive memory loss cognitive decline, significantly impairing daily life. In contrast, FTD marked selective degeneration frontal and/or temporal lobes, typically resulting profound changes personality social behavior, speech disorders, psychiatric symptoms. Numerous studies have found microRNAs (miRNAs)-small, non-coding RNA molecules that regulate gene expression post-transcriptionally-to be dysregulated FTD. As a result, miRNAs emerged as promising novel biomarkers for these diseases. This review examines current understanding FTD, emphasizing their potential accessible, noninvasive diagnosing prevalent neurodegenerative disorders.

Language: Английский

Citations

0
PRDM16-DT is a Brain and Astrocyte-Specific lncRNA Implicated in Alzheimers Disease DOI
Sophie Schröder,

Ulrike Fuchs,

Verena Gisa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Abstract Astrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic maintenance, and neurotransmitter recycling. Under pathological conditions, deregulation of astrocytes contributes neurodegenerative diseases such as Alzheimer’s disease (AD), highlighting the growing interest in targeting astrocyte function address early phases AD pathogenesis. While most research this field has focused on protein-coding genes, non-coding RNAs, particularly long RNAs (lncRNAs), have emerged significant regulatory molecules. In study, we identified lncRNA PRDM16-DT highly enriched human brain, where it is almost exclusively expressed astrocytes. its murine homolog, Prdm16os , are downregulated brains patients models. line with this, knockdown revealed critical role maintaining homeostasis supporting neuronal by regulating genes essential glutamate uptake, lactate release, spine density through interactions RE1-Silencing Transcription factor (Rest) Polycomb Repressive Complex 2 (PRC2). Notably, CRISPR-mediated overexpression mitigated functional deficits induced stimuli linked These findings underscore importance potential a novel therapeutic target disorders characterized dysfunction

Language: Английский

Citations

2