Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity DOI Creative Commons

Adriana Casillas Martinez,

Leigh E. Wicki‐Stordeur, Annika V. Ariano

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Abstract Pannexin 1 (PANX1) is an ion and metabolite membrane channel scaffold protein enriched in synaptic compartments of neurons the central nervous system. In addition to a well‐established link between PANX1 plasticity, we recently identified role for regulation dendritic spine stability. Notably, its interacting proteins are linked neurological conditions involving loss. Understanding dual function morphology may help shed light on these links. We explore potential mechanisms, including PANX1's interactions with postsynaptic receptors cytoskeleton regulating proteins. Finally, contextualize within diseases synapse dysfunction. image

Language: Английский

Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity DOI Creative Commons

Adriana Casillas Martinez,

Leigh E. Wicki‐Stordeur, Annika V. Ariano

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Abstract Pannexin 1 (PANX1) is an ion and metabolite membrane channel scaffold protein enriched in synaptic compartments of neurons the central nervous system. In addition to a well‐established link between PANX1 plasticity, we recently identified role for regulation dendritic spine stability. Notably, its interacting proteins are linked neurological conditions involving loss. Understanding dual function morphology may help shed light on these links. We explore potential mechanisms, including PANX1's interactions with postsynaptic receptors cytoskeleton regulating proteins. Finally, contextualize within diseases synapse dysfunction. image

Language: Английский

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