Parkinson’s disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain in PD-related genes, including PARK19 (DNAJC6) and PTPRN2 (IA-2β) DOI
Juliana Choza, Mahek Virani,

Nathan C. Kuhn

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 15, 2024

The majority of Parkinson's disease (PD) cases are due to a complex interaction between aging, genetics, and environmental factors; epigenetic mechanisms thought act as important mediators these risk factors. While multiple studies date have explored the role DNA modifications in PD, few focus on 5-hydroxymethylcytosine (5hmC). Because 5hmC occurs at its highest levels brain is be particularly central nervous system, response neurotoxicants, it explore potential PD. This study expands our previously published epigenome-wide association (EWAS) performed isolated from neuron-enriched nuclei human postmortem parietal cortex Banner Sun Health Research Institute Brain Bank. aimed identify paired changes 5mC PD enriched neuronal post-mortem age- sex-matched controls. We oxidative bisulfite (oxBS) conversion with (BS)-based EWAS same samples cytosines significant shifts two related marks. Interaction differentially modified (iDMCs) were identified using recently mixed-effects model for co-analyzing β

Language: Английский

Exposure to pesticides and cognitive function in school-age children of the Bolivar Department (Colombia) DOI

M. Quintana-Mejia,

Flor Palacio-Herrera,

Jesús Olívero-Verbel

et al.

Toxicology Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Emerging Roles of Histone modifications in Environmental Toxicants-Induced Neurotoxicity DOI
Ishita Mehta,

Manika Verma,

Mohammed Nazish Quasmi

et al.

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154164 - 154164

Published: April 1, 2025

Language: Английский

Citations

0
Parkinson’s disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain DOI Creative Commons
Juliana Choza, Mahek Virani,

Nathan C. Kuhn

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 22, 2024

Abstract Epigenetic mechanisms are mediators of interactions between aging, genetics, and environmental factors in sporadic Parkinson’s disease (PD). Multiple studies have explored the DNA modifications PD, but few focus on 5-hydroxymethylcytosine (5-hmC), which is important central nervous system sensitive to exposures. To date, not differentiated 5-methylcytosine (5-mC) 5-hmC or analyzed them separately. In this study, we modeled paired 5-mC data simultaneously. We identified 108 cytosines with significant PD-associated shifts these marks an enriched neuronal population from PD postmortem parietal cortex, within 83 genes 34 enhancers associated 67 genes. These potentially link epigenetic regulation related LRRK2 endolysosomal sort ( RAB32 AGAP1 ), involved neuroinflammation, inflammasome, neurodevelopment early changes suggest that there 5mC 5hmC captured by standard methods.

Language: Английский

Citations

1
Parkinson’s disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain in PD-related genes, including PARK19 (DNAJC6) and PTPRN2 (IA-2β) DOI
Juliana Choza, Mahek Virani,

Nathan C. Kuhn

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 15, 2024

The majority of Parkinson's disease (PD) cases are due to a complex interaction between aging, genetics, and environmental factors; epigenetic mechanisms thought act as important mediators these risk factors. While multiple studies date have explored the role DNA modifications in PD, few focus on 5-hydroxymethylcytosine (5hmC). Because 5hmC occurs at its highest levels brain is be particularly central nervous system, response neurotoxicants, it explore potential PD. This study expands our previously published epigenome-wide association (EWAS) performed isolated from neuron-enriched nuclei human postmortem parietal cortex Banner Sun Health Research Institute Brain Bank. aimed identify paired changes 5mC PD enriched neuronal post-mortem age- sex-matched controls. We oxidative bisulfite (oxBS) conversion with (BS)-based EWAS same samples cytosines significant shifts two related marks. Interaction differentially modified (iDMCs) were identified using recently mixed-effects model for co-analyzing β

Language: Английский

Citations

0