Magnetogenetic stimulation inside MRI induces spontaneous and evoked changes in neural circuits activity in rats

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 1, 2024

The ability to modulate specific neural circuits and simultaneously visualize measure brain activity with MRI would greatly impact our understanding of function in health disease. combination neurostimulation methods functional animal models have already shown promise elucidating fundamental mechanisms associated activity. We developed an innovative magnetogenetics technology that can trigger through magnetic fields. Similar other genetic-based neuromodulation methods, offers cell-, area-, temporal-specific control magnetogenetic protein—Electromagnetic Perceptive Gene (EPG)—is activated by non-invasive fields, providing a unique way target the static gradient fields while measuring their effect on EPG was expressed rat's visual cortex amplitude low-frequency fluctuation, resting-state connectivity (FC), sensory activation measured using 7T MRI. results demonstrate EPG-expressing rats had significantly higher signal fluctuations areas stronger FC consistent known anatomical visuosensory visuomotor connections. This new complements existing toolbox provides means study minimally-invasive which not possible previously.

Language: Английский

Quantitative spinal cord imaging: Early ALS diagnosis and monitoring of disease progression

Revue Neurologique, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский