Opposing effects of rewarding and aversive stimuli on D1 and D2 types of dopamine-sensitive neurons in the central amygdala DOI Creative Commons
Anna Beroun, Łukasz Bijoch,

Paweł Szczypkowski

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Dopamine-sensitive neurons are organized in two classes of cells, expressing D1- or D2- types dopamine receptors, and often mediating opposing aspects reward-oriented behaviors. Here, we focused on dopamine-sensitive the central amygdala – a brain structure critically involved processing emotion-related stimuli. Exposing mice to rewarding aversive stimuli studied DRD1 DRD2 cells activity using in vivo two-photon calcium imaging CeM. We showed that cocaine sugar predominantly increase DRD1(+) decrease DRD2(+) cells. Repeated exposure cocaine, however, had opposite effect spontaneous excitatory synaptic transmission CeM than sugar. Quinine, an stimulus, primarily engaged neurons, activating those were previously inhibited by exposure. Our results show though populations differentially regulated appetitive/aversive stimuli, both participate sugar, quinine processing.

Language: Английский

Opposing effects of rewarding and aversive stimuli on D1 and D2 types of dopamine-sensitive neurons in the central amygdala DOI Open Access
Łukasz Bijoch,

Paweł Szczypkowski,

Justyna Wiśniewska

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Dopamine-sensitive neurons are organized in two classes of cells, expressing D1- or D2- types dopamine receptors, and often mediating opposing aspects reward-oriented behaviors. Here, we focused on dopamine-sensitive the central amygdala – a brain structure critically involved processing emotion-related stimuli. We discovered that both receptor present medial nucleus, while lateral part is populated predominantly with DRD2 cells. Exposing mice to rewarding aversive stimuli studied DRD1 cells activity using vivo two-photon calcium imaging CeM. showed cocaine sugar increase DRD1(+) decrease DRD2(+) Repeated exposure cocaine, however, had opposite effect spontaneous excitatory synaptic transmission CeM than sugar. Quinine, an stimulus, primarily engaged neurons, activating those were previously inhibited by exposure. Our results show though populations differentially regulated appetitive/aversive stimuli, participate sugar, quinine processing.

Language: Английский

Citations

1
Opposing effects of rewarding and aversive stimuli on D1 and D2 types of dopamine-sensitive neurons in the central amygdala DOI Creative Commons
Anna Beroun, Łukasz Bijoch,

Paweł Szczypkowski

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Dopamine-sensitive neurons are organized in two classes of cells, expressing D1- or D2- types dopamine receptors, and often mediating opposing aspects reward-oriented behaviors. Here, we focused on dopamine-sensitive the central amygdala – a brain structure critically involved processing emotion-related stimuli. Exposing mice to rewarding aversive stimuli studied DRD1 DRD2 cells activity using in vivo two-photon calcium imaging CeM. We showed that cocaine sugar predominantly increase DRD1(+) decrease DRD2(+) cells. Repeated exposure cocaine, however, had opposite effect spontaneous excitatory synaptic transmission CeM than sugar. Quinine, an stimulus, primarily engaged neurons, activating those were previously inhibited by exposure. Our results show though populations differentially regulated appetitive/aversive stimuli, both participate sugar, quinine processing.

Language: Английский

Citations

0