Bioorthogonal Labeling and Enrichment of Histone Monoaminylation Reveal Its Accumulation and Regulatory Function in Cancer Cell Chromatin

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(24), P. 16714 - 16720

Published: June 7, 2024

Histone monoaminylation (

Language: Английский

Transglutaminase 2-mediated Histone Monoaminylation and Its Role in Cancer

Bioscience Reports, Journal Year: 2024, Volume and Issue: 44(8)

Published: Aug. 1, 2024

Abstract Transglutaminase 2 (TGM2) has been known as a well-characterized factor regulating the progression of multiple types cancer, due to its multifunctional activities and ubiquitous signaling pathways it is involved in. As member transglutaminase family, TGM2 catalyzes protein post-translational modifications (PTMs), including monoaminylation, amide hydrolysis, cross-linking, etc., through transamidation variant glutamine-containing substrates. Recent discoveries revealed histone an important category substrates, thus identifying monoaminylation emerging epigenetic mark, which highly enriched in cancer cells possesses significant regulatory functions gene transcription. In this review, we will summarize recent advances TGM2-mediated well role discuss key research methodologies better understand unique thereby shedding light on therapeutic potential druggable target treatment.

Language: Английский

Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer

Cancer Letters, Journal Year: 2024, Volume and Issue: 600, P. 217150 - 217150

Published: Aug. 2, 2024

Language: Английский