Persistence of an Infectious Form of SARS-CoV-2 After Protease Inhibitor Treatment of Permissive Cells In Vitro DOI Creative Commons
Manoj S. Nair,

Maria I. Luck,

Yaoxing Huang

et al.

The Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Reports have described SARS-CoV-2 rebound in COVID-19 patients treated with nirmatrelvir, a 3CL protease inhibitor. The cause remains mystery, although drug resistance, re-infection, and lack of adequate immune responses been excluded. We now present virologic findings that provide clue to the viral rebound, which occurs ∼20% cases. Persistence infectious was experimentally documented vitro after treatment nirmatrelvir or another inhibitor, but not polymerase remdesivir. This form decayed slowly half-life ∼1 day, suggesting its persistence could outlive course re-ignite infection as is eliminated. Notably, extending beyond 8 days abolished vitro. Our point particular direction for future investigation virus offer specific recommendation should be tested clinically.

Language: Английский

Persistence of an Infectious Form of SARS-CoV-2 After Protease Inhibitor Treatment of Permissive Cells In Vitro DOI Creative Commons
Manoj S. Nair,

Maria I. Luck,

Yaoxing Huang

et al.

The Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Reports have described SARS-CoV-2 rebound in COVID-19 patients treated with nirmatrelvir, a 3CL protease inhibitor. The cause remains mystery, although drug resistance, re-infection, and lack of adequate immune responses been excluded. We now present virologic findings that provide clue to the viral rebound, which occurs ∼20% cases. Persistence infectious was experimentally documented vitro after treatment nirmatrelvir or another inhibitor, but not polymerase remdesivir. This form decayed slowly half-life ∼1 day, suggesting its persistence could outlive course re-ignite infection as is eliminated. Notably, extending beyond 8 days abolished vitro. Our point particular direction for future investigation virus offer specific recommendation should be tested clinically.

Language: Английский

Citations

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