Topologically distinct and equivalent multiple efferent arterioles in the human glomeruli DOI Creative Commons
Joshua Li, Jeremy Yuen‐Chun Teoh, H. M. Lai

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

Abstract We revisit the assumption that human glomerulus consists of a capillary network with one afferent arteriole and only efferent arteriole. Using three-dimensional tissue imaging, we unambiguously demonstrate existence multiple arterioles via total reconstruction full glomerular network. Through graph analysis, found these can be topologically distinct or equivalent reference to global network, were strategically positioned respect also extraglomerular connections between two may have significant contributions redistribution intraglomerular blood flow. These new findings provide paradigms in regulation dysfunction ultrafiltration, crosstalk intra- factors, cross-coupling nephrons.

Language: Английский

Topologically distinct and equivalent multiple efferent arterioles in the human glomeruli DOI Creative Commons
Joshua Li, Jeremy Yuen‐Chun Teoh, H. M. Lai

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

Abstract We revisit the assumption that human glomerulus consists of a capillary network with one afferent arteriole and only efferent arteriole. Using three-dimensional tissue imaging, we unambiguously demonstrate existence multiple arterioles via total reconstruction full glomerular network. Through graph analysis, found these can be topologically distinct or equivalent reference to global network, were strategically positioned respect also extraglomerular connections between two may have significant contributions redistribution intraglomerular blood flow. These new findings provide paradigms in regulation dysfunction ultrafiltration, crosstalk intra- factors, cross-coupling nephrons.

Language: Английский

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