Model of a striatal circuit exploring biological mechanisms underlying decision-making during normal and disordered states DOI Open Access

Dirk W. Beck,

Cory N. Heaton,

Luis D. Davila

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Decision-making requires continuous adaptation to internal and external contexts. Changes in decision-making are reliable transdiagnostic symptoms of neuropsychiatric disorders. We created a computational model demonstrating how the striosome compartment striatum constructs mathematical space for computations depending on context, matrix defines action value space. The explains multiple experimental results unifies other theories like reward prediction error, roles direct versus indirect pathways, matrix, under one framework. also found, through new analyses, that neurons increase their synchrony during difficult tasks, caused by necessary dimensionality makes testable predictions about individual differences disorder susceptibility, shared among disorders, symptom presentation. reframes role striosomal circuit neuroeconomic disorder-affected decision-making.

Language: Английский

Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence DOI Creative Commons

Sarah Hawes,

Bo Liang, Braden Oldham

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Abstract Spiny projection neurons (SPNs) in the dorsal striatum play crucial roles locomotion control and value-based decision-making. SPNs, which include both direct-pathway striatonigral indirect-pathway striatopallidal neurons, can be further classified into subtypes based on distinct transcriptomic profiles cell body distribution patterns. However, how these SPN regulate spontaneous context of environmental valence remains unclear. Using Sepw1 - Cre transgenic mice, label a specific subtype characterized by patchy bodies striatum, we found that constrain motor vigor response to differentials. In modified light/dark box test, mice exhibited differential walking speeds between light dark zones. Genetic ablation SPNs disrupted restful slowing zone increased transition frequencies vivo recordings linked activity occupancy, speed, deceleration, with role mediating deceleration. Furthermore, chemogenetic activation SPNs—and optical particular—reduced attenuated speed-based discrimination. These findings reveal regulates implicit speed selection innate

Language: Английский

Citations

0
Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion DOI Creative Commons
Jie Dong, Lupeng Wang, Breanna T. Sullivan

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 19, 2025

Abstract Striatonigral neurons, traditionally known for promoting locomotion, comprise diverse subtypes with distinct transcriptomic profiles. However, their specific contributions to locomotor regulation remain incompletely understood. Using the genetic markers Kremen1 and Calb1 , we demonstrate in mouse models that + striatonigral neurons exerted opposing effects on locomotion. displayed delayed activation at locomotion onset but exhibited increasing activity during offset. In contrast, showed early decreasing Optogenetic of suppressed ongoing whereas promoted Activation induced a greater reduction dopamine release than followed by post-stimulation rebound. Conversely, triggered an initial increase release. Furthermore, knockdown GABA-B receptor Gabbr1 Aldh1a1 nigrostriatal dopaminergic (DANs) reduced DAN inhibition completely abolished locomotion-suppressing effect neurons. Together, these findings reveal cell type-specific mechanism within neuron subtypes: promote while terminate movement inhibiting via GABBR1 receptors.

Language: Английский

Citations

0
Developmental and Adult Striatal Patterning of Nociceptin Ligand Marks Striosomal Population With Direct Dopamine Projections DOI Creative Commons
Emily Hueske, Carrie Stine, Tomoko Yoshida

et al.

The Journal of Comparative Neurology, Journal Year: 2024, Volume and Issue: 532(12)

Published: Dec. 1, 2024

Circuit influences on the midbrain dopamine system are crucial to adaptive behavior and cognition. Recent developments in study of neuropeptide systems have enabled high-resolution investigations intersection neuromodulatory signals with basal ganglia circuitry, identifying nociceptin/orphanin FQ (N/OFQ) endogenous opioid peptide as a prospective regulator striatal signaling. Using prepronociceptin-Cre reporter mouse line, we characterized highly selective striosomal patterning Pnoc mRNA expression dorsal striatum, reflecting early developmental Pnoc. In ventral nucleus accumbens core was grouped clusters akin distribution found striosomes. We that

Language: Английский

Citations

2
Model of a striatal circuit exploring biological mechanisms underlying decision-making during normal and disordered states DOI Open Access

Dirk W. Beck,

Cory N. Heaton,

Luis D. Davila

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Decision-making requires continuous adaptation to internal and external contexts. Changes in decision-making are reliable transdiagnostic symptoms of neuropsychiatric disorders. We created a computational model demonstrating how the striosome compartment striatum constructs mathematical space for computations depending on context, matrix defines action value space. The explains multiple experimental results unifies other theories like reward prediction error, roles direct versus indirect pathways, matrix, under one framework. also found, through new analyses, that neurons increase their synchrony during difficult tasks, caused by necessary dimensionality makes testable predictions about individual differences disorder susceptibility, shared among disorders, symptom presentation. reframes role striosomal circuit neuroeconomic disorder-affected decision-making.

Language: Английский

Citations

1