The Circulating Proteome─Technological Developments, Current Challenges, and Future Trends

Journal of Proteome Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Recent improvements in proteomics technologies have fundamentally altered our capacities to characterize human biology. There is an ever-growing interest using these novel methods for studying the circulating proteome, as blood offers accessible window into health. However, every methodological innovation and analytical progress calls reassessing existing approaches routines ensure that new data will add value greater biomedical research community avoid previous errors. As representatives of HUPO's Human Plasma Proteome Project (HPPP), we present 2024 survey current community, including latest build PeptideAtlas now comprises 4608 proteins detected 113 sets. We then discuss updates established methods, emerging technologies, investigations proteoforms, protein networks, extracellualr vesicles, antibodies microsamples. Finally, provide a prospective view tools studies proteins.

Language: Английский

Bridging the Gap from Proteomics Technology to Clinical Application: Highlights from the 68th Benzon Foundation Symposium

Molecular & Cellular Proteomics, Journal Year: 2024, Volume and Issue: unknown, P. 100877 - 100877

Published: Nov. 1, 2024

Language: Английский