The “Ins and Outs and What-Abouts” of H2A.Z: A Tribute to C. David Allis DOI Creative Commons

Felix Diegmüller,

Jörg Leers,

Sandra B. Hake

et al.

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: 301(2), P. 108154 - 108154

Published: Jan. 4, 2025

In 2023, the brilliant chromatin biologist C. David Allis passed away leaving a large void in scientific community and broken hearts his family friends. With this review, we want to tribute Dave's enduring inspiration by focusing on histone variant H2A.Z, nucleosome component he was first discover as hv1 Tetrahymena. We summarize latest findings from past 5 years regarding mammalian H2A.Z histone, its deposition eviction mechanisms, roles transcriptional regulation, DNA damage repair, structure organization, embryonic development, well how deregulation or mutation(s) of chaperones contribute disease development. As Dave liked say 'Every amino acid matters'; discovery characterization functionally different H2A.Z's isoforms, which vary only three acids, prove him-once again-right.

Language: Английский

The “Ins and Outs and What-Abouts” of H2A.Z: A Tribute to C. David Allis DOI Creative Commons

Felix Diegmüller,

Jörg Leers,

Sandra B. Hake

et al.

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: 301(2), P. 108154 - 108154

Published: Jan. 4, 2025

In 2023, the brilliant chromatin biologist C. David Allis passed away leaving a large void in scientific community and broken hearts his family friends. With this review, we want to tribute Dave's enduring inspiration by focusing on histone variant H2A.Z, nucleosome component he was first discover as hv1 Tetrahymena. We summarize latest findings from past 5 years regarding mammalian H2A.Z histone, its deposition eviction mechanisms, roles transcriptional regulation, DNA damage repair, structure organization, embryonic development, well how deregulation or mutation(s) of chaperones contribute disease development. As Dave liked say 'Every amino acid matters'; discovery characterization functionally different H2A.Z's isoforms, which vary only three acids, prove him-once again-right.

Language: Английский

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