Modulation of Sensory Input to the Spinal Cord by Peripheral Afferent Fibres via GABAergic Astrocytes DOI Creative Commons
Urszula Sławińska, Ingela Hammar, E. Jankowska

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(6)

Published: March 1, 2025

ABSTRACT A long‐lasting GABA‐dependent increase in the excitability of afferent fibres, and thus modulation sensory input to spinal cord, may be evoked by epidural polarization. However, direct effects fibre polarization are short‐lasting sustained their appears secondary release GABA from nearby astrocytes. We have now investigated whether stimulation a peripheral nerve, previously attributed synaptically intraspinal field potentials, is similar way. as neither its dependence on nor relays been investigated, we addressed question epidurally stimulated fibres following nerve does or not depend it might mediated The conditioning tibial were evaluated changes both Group I II muscle afferents, estimated action potentials recorded nerves dorsal horn respectively acute experiments deeply anaesthetized rats. afferents was increased and/or cutaneous but afferents. significantly weakened blocking channels gabazine astrocyte toxin L‐alpha‐aminoadipic acid (L‐AAA), indicating that modulated GABAergic astrocytes, new role played

Language: Английский

Modulation of Sensory Input to the Spinal Cord by Peripheral Afferent Fibres via GABAergic Astrocytes DOI Creative Commons
Urszula Sławińska, Ingela Hammar, E. Jankowska

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(6)

Published: March 1, 2025

ABSTRACT A long‐lasting GABA‐dependent increase in the excitability of afferent fibres, and thus modulation sensory input to spinal cord, may be evoked by epidural polarization. However, direct effects fibre polarization are short‐lasting sustained their appears secondary release GABA from nearby astrocytes. We have now investigated whether stimulation a peripheral nerve, previously attributed synaptically intraspinal field potentials, is similar way. as neither its dependence on nor relays been investigated, we addressed question epidurally stimulated fibres following nerve does or not depend it might mediated The conditioning tibial were evaluated changes both Group I II muscle afferents, estimated action potentials recorded nerves dorsal horn respectively acute experiments deeply anaesthetized rats. afferents was increased and/or cutaneous but afferents. significantly weakened blocking channels gabazine astrocyte toxin L‐alpha‐aminoadipic acid (L‐AAA), indicating that modulated GABAergic astrocytes, new role played

Language: Английский

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