Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)
Published: Dec. 19, 2024
Language: Английский
Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
2
Ultrasonics, Journal Year: 2025, Volume and Issue: 148, P. 107564 - 107564
Published: Jan. 5, 2025
Language: Английский
Citations
1
Brain stimulation, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Transcranial ultrasonic stimulation (TUS) redefines what is possible with non-invasive neuromodulation by oaering unparalleled spatial precision and flexible targeting capabilities. However, peripheral confounds pose a significant challenge to reliably implementing this technology. While auditory during TUS have been studied extensively, the somatosensory confound has overlooked thus far. It will become increasingly vital quantify manage as field shifts towards higher doses, more compact devices, frequent through temple where co-stimulation pronounced. Here, we provide systematic characterisation of TUS. We also identify conditions under which can be mitigated most eaectively mapping confound-parameter space. Specifically, investigate dose-response eaects, pulse shaping characteristics, transducer-specific parameters. demonstrate that avoiding near-field intensity peaks in scalp, spreading energy across greater area ramping envelope, delivering equivalent doses via longer, lower-intensity pulses rather than shorter, higher-intensity pulses. Additionally, repetition frequencies fundamental reduce eaects. Through our parameter space, find preliminary evidence particle displacement (strain) may primary biophysical driving force behind co-stimulation. This study provides actionable strategies minimise confounds, support thorough experimental control required unlock full potential for scientific research clinical interventions. Tactile, thermal, even painful occur TUS.Confounds & parameters.Valid replicable requires confounds.Particle confounds.
Language: Английский
Citations
0
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 19, 2025
Transcranial ultrasound stimulation (TUS) offers precise, non-invasive neuromodulation, though its impact on human deep brain structures remains underexplored. Here we examined TUS-induced changes in the basal ganglia of 10 individuals with movement disorders (Parkinson's disease and dystonia) 15 healthy participants. Local field potentials were recorded using (DBS) leads globus pallidus internus (GPi). Compared to sham, theta burst TUS (tbTUS) increased power during stimulation, while Hz enhanced beta power, effects lasting up 40 min. In participants, a stop-signal task assessed tbTUS GPi, pulvinar serving as an active sham. GPi prolonged reaction times, indicating impaired response inhibition, whereas had no effect. These findings provide direct electrophysiological evidence target engagement specificity structures, suggesting potential noninvasive DBS strategy for neurological psychiatric disorders. is method modulate activity. Using recordings from implanted electrodes, showed that engages internus, neural oscillations behavior.
Language: Английский
Citations
0
Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)
Published: Dec. 19, 2024
Language: Английский
Citations
2