TAMing Gliomas: Unraveling the Roles of Iba1 and CD163 in Glioblastoma DOI Open Access

Haneya Fuse,

Yuqi Zheng, Islam Alzoubi

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1457 - 1457

Published: April 26, 2025

Gliomas, the most common type of primary brain tumor, are a significant cause morbidity and mortality worldwide. Glioblastoma, highly malignant subtype, is particularly common, aggressive, resistant to treatment. The tumor microenvironment (TME) gliomas, especially glioblastomas, characterized by distinct presence tumor-associated macrophages (TAMs), which densely infiltrate hallmark these tumors. This macrophage population comprises both tissue-resident microglia as well derived from walls blood vessels stream. Ionized calcium-binding adapter molecule 1 (Iba1) CD163 established cellular markers that enable identification functional characterization cells within TME. review provides an in-depth examination roles Iba1 in with focus on TAM activation, migration, immunomodulatory functions. Additionally, we will discuss how recent advances AI-enhanced cell visualization techniques have begun transform analysis TAMs, promising unprecedented precision their providing new insights into appear unique shared glioma pathobiology, potential be targeted through different molecular mechanisms. We therapeutic based available preclinical (experimental) clinical (human tissue-based) evidence.

Language: Английский

TAMing Gliomas: Unraveling the Roles of Iba1 and CD163 in Glioblastoma DOI Open Access

Haneya Fuse,

Yuqi Zheng, Islam Alzoubi

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1457 - 1457

Published: April 26, 2025

Gliomas, the most common type of primary brain tumor, are a significant cause morbidity and mortality worldwide. Glioblastoma, highly malignant subtype, is particularly common, aggressive, resistant to treatment. The tumor microenvironment (TME) gliomas, especially glioblastomas, characterized by distinct presence tumor-associated macrophages (TAMs), which densely infiltrate hallmark these tumors. This macrophage population comprises both tissue-resident microglia as well derived from walls blood vessels stream. Ionized calcium-binding adapter molecule 1 (Iba1) CD163 established cellular markers that enable identification functional characterization cells within TME. review provides an in-depth examination roles Iba1 in with focus on TAM activation, migration, immunomodulatory functions. Additionally, we will discuss how recent advances AI-enhanced cell visualization techniques have begun transform analysis TAMs, promising unprecedented precision their providing new insights into appear unique shared glioma pathobiology, potential be targeted through different molecular mechanisms. We therapeutic based available preclinical (experimental) clinical (human tissue-based) evidence.

Language: Английский

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