Developmental decorrelation of local cortical activity through adolescence supports high-dimensional encoding and working memory DOI Creative Commons
Finnegan J. Calabro,

Dylan LeCroy,

Will Foran

et al.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 73, P. 101541 - 101541

Published: March 4, 2025

Adolescence is a key period for the maturation of cognitive control during which cortical circuitry refined through processes such as synaptic pruning, but how these refinements modulate local functional dynamics to support cognition remains only partially characterized. Here, we used data from longitudinal, adolescent cohort (N = 134 individuals ages 10-31 years, N 202 total sessions) that completed MRI scans at ultra-high field (7 Tesla). We resting state fMRI compute surface-based regional homogeneity (ReHo)-a measure time-dependent correlations in activity between vertex and its immediate neighbors-as an index connectivity across cortex. found widespread decreases ReHo, suggesting increasing heterogeneity specialization circuits adolescence. Decreases ReHo included spatial component overlapped with sensorimotor cingulo-opercular networks, were associated developmental stabilization working memory performance. show are higher intrinsic coding dimensionality, demonstrating may confer computational benefits by facilitating increased capacity encoding information. These results suggest remodeling adolescence become increasingly specialized, higher-dimensional, more capable supporting adult-like functioning.

Language: Английский

Heterochronous laminar maturation in the human prefrontal cortex DOI Creative Commons
Valerie J. Sydnor, Daniel Petrie, Shane D. McKeon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

The human prefrontal cortex (PFC) exhibits markedly protracted developmental plasticity, yet whether reductions in plasticity occur synchronously across cortical layers is unclear. Animal studies have shown that intracortical myelin consolidates neural circuits to close periods of plasticity. Here, we use quantitative imaging collected from youth (ages 10-32 years) at ultra-high field (7T) investigate deep and superficial PFC exhibit different timeframes We find matures along a deep-to-superficial axis the PFC; this maturational timing expressed extent cytoarchitecturally distinct regions frontal hierarchy. By integrating mapping with electroencephalogram cognitive phenotyping, provide evidence dissociably impact timescales activity, task learning rates, processing speed. Heterochronous maturation an underrecognized mechanism through which association balances cognitively-relevant increases circuit stability efficiency extended neuroplasticity.

Language: Английский

Citations

0
Developmental decorrelation of local cortical activity through adolescence supports high-dimensional encoding and working memory DOI Creative Commons
Finnegan J. Calabro,

Dylan LeCroy,

Will Foran

et al.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 73, P. 101541 - 101541

Published: March 4, 2025

Adolescence is a key period for the maturation of cognitive control during which cortical circuitry refined through processes such as synaptic pruning, but how these refinements modulate local functional dynamics to support cognition remains only partially characterized. Here, we used data from longitudinal, adolescent cohort (N = 134 individuals ages 10-31 years, N 202 total sessions) that completed MRI scans at ultra-high field (7 Tesla). We resting state fMRI compute surface-based regional homogeneity (ReHo)-a measure time-dependent correlations in activity between vertex and its immediate neighbors-as an index connectivity across cortex. found widespread decreases ReHo, suggesting increasing heterogeneity specialization circuits adolescence. Decreases ReHo included spatial component overlapped with sensorimotor cingulo-opercular networks, were associated developmental stabilization working memory performance. show are higher intrinsic coding dimensionality, demonstrating may confer computational benefits by facilitating increased capacity encoding information. These results suggest remodeling adolescence become increasingly specialized, higher-dimensional, more capable supporting adult-like functioning.

Language: Английский

Citations

0