Beyond COVID-19: the promise of next-generation coronavirus vaccines DOI Creative Commons

Reshma Koolaparambil Mukesh,

Claude Kwe Yinda, Vincent J. Munster

et al.

npj Viruses, Journal Year: 2024, Volume and Issue: 2(1)

Published: Aug. 22, 2024

Abstract Coronaviruses (CoVs) have caused three global outbreaks: severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) in 2003, Middle East (MERS-CoV) 2012, and SARS-CoV-2 2019, with significant mortality morbidity. The impact of disease 2019 (COVID-19) raised serious concerns about the preparedness for a pandemic. Furthermore, changing antigenic landscape led to new variants increased transmissibility immune evasion. Thus, development broad-spectrum vaccines against current future emerging CoVs will be an essential tool pandemic preparedness. Distinct phylogenetic features within complicate limit process generating pan-CoV vaccine capable targeting entire Coronaviridae family. In this review, we aim provide detailed overview CoVs, their phylogeny, various efforts developing vaccines, future.

Language: Английский

Beyond COVID-19: the promise of next-generation coronavirus vaccines DOI Creative Commons

Reshma Koolaparambil Mukesh,

Claude Kwe Yinda, Vincent J. Munster

et al.

npj Viruses, Journal Year: 2024, Volume and Issue: 2(1)

Published: Aug. 22, 2024

Abstract Coronaviruses (CoVs) have caused three global outbreaks: severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) in 2003, Middle East (MERS-CoV) 2012, and SARS-CoV-2 2019, with significant mortality morbidity. The impact of disease 2019 (COVID-19) raised serious concerns about the preparedness for a pandemic. Furthermore, changing antigenic landscape led to new variants increased transmissibility immune evasion. Thus, development broad-spectrum vaccines against current future emerging CoVs will be an essential tool pandemic preparedness. Distinct phylogenetic features within complicate limit process generating pan-CoV vaccine capable targeting entire Coronaviridae family. In this review, we aim provide detailed overview CoVs, their phylogeny, various efforts developing vaccines, future.

Language: Английский

Citations

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