A hierarchical immune receptor network in lettuce reveals contrasting patterns of evolution in sensor and helper NLRs DOI Creative Commons
Hsuan Pai, Toshiyuki Sakai, Andrés Posbeyikian

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

ABSTRACT Nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) are known for their rapid evolution, even at the intraspecific level, yet rates of evolution differ significantly across various NLR classes. Within NRC (NLR Required Cell Death) network, NLRs operate in complex sensor-helper configurations to confer immunity against a diverse array pathogens, particularly Asterids. While helper typically conserved evolve slowly, sensor tend more rapidly. However, functional connections between slow fast-evolving remain poorly understood, notably important crop species. We conducted comparative analysis 40 Solanales 29 Asterales genomes explore network expansion diversification within less-studied order. Our findings reveal that has expanded less compared Solanales. functionally validated minimal with 2 helpers 9 sensors common lettuce ( Lactuca sativa ). Through selection structural modeling subclades genus, we found varying evolutionary sensors. correlation dependency, reliant on phylogenetically experiencing limited pressure. results highlight lineage- function-specific offering insights into pressures shaping plant receptor networks.

Language: Английский

A hierarchical immune receptor network in lettuce reveals contrasting patterns of evolution in sensor and helper NLRs DOI Creative Commons
Hsuan Pai, Toshiyuki Sakai, Andrés Posbeyikian

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

ABSTRACT Nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) are known for their rapid evolution, even at the intraspecific level, yet rates of evolution differ significantly across various NLR classes. Within NRC (NLR Required Cell Death) network, NLRs operate in complex sensor-helper configurations to confer immunity against a diverse array pathogens, particularly Asterids. While helper typically conserved evolve slowly, sensor tend more rapidly. However, functional connections between slow fast-evolving remain poorly understood, notably important crop species. We conducted comparative analysis 40 Solanales 29 Asterales genomes explore network expansion diversification within less-studied order. Our findings reveal that has expanded less compared Solanales. functionally validated minimal with 2 helpers 9 sensors common lettuce ( Lactuca sativa ). Through selection structural modeling subclades genus, we found varying evolutionary sensors. correlation dependency, reliant on phylogenetically experiencing limited pressure. results highlight lineage- function-specific offering insights into pressures shaping plant receptor networks.

Language: Английский

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