Multiple developmental pathways in organisms with developmentally complex life cycles DOI Creative Commons
Giuseppe Fusco, Alessandro Minelli

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: May 14, 2025

One aspect under which an organism's life cycle can be considered complex is when the very same organism undertake, or obligatorily undertakes, multiple developmental pathways. Examples are organisms with alternation of generations, like most plants, reproductive and/or options, many marine invertebrates. With a broad taxonomic coverage across eukaryotes, we survey these developmentally cycles, presenting selected case studies to illustrate relationships between diverse pathways within for what concerns morphogenesis and gene expression. We highlight deep connections different types cycles show their relationship phenotypic plasticity, sexual dimorphism ecological adaptation. The collected materials organized concepts provide basis future investigations on disparity evolution tree life.

Language: Английский

A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian DOI Creative Commons
Camille Curantz,

Ciara Doody,

Helen R Horkan

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(2)

Published: Jan. 8, 2025

The fertile gonad includes cells of two distinct developmental origins: the somatic mesoderm and germ line. How interact to develop maintain fertility is not well understood. Here, using grafting experiments transgenic reporter animals, we find that a specific part gonad—the germinal zone—acts as sexual organizer induce de novo gonads in cnidarian Hydractinia symbiolongicarpus . Germ express member transforming growth factor–β family, Gonadless ( Gls ), induces morphogenesis. Loss resulted animals lacking but having nonproliferative cells. We propose primary drive development though secretion. zone newly formed provides positive feedback secondary by activating Tfap2 resident pluripotent stem contribution cell signaling patterning gonadal tissue may be general animal feature.

Language: Английский

Citations

1
BarQC: Quality Control and Preprocessing for SPLiT-Seq Data DOI Creative Commons
Maria Rosselló, Sophie Tandonnet, Isabel Almudí

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Abstract Summary SPLiT-seq is a cost-effective single-cell RNA-sequencing method, easy to implement in most laboratories. However, the data preprocessing not straightforward, and no solution currently exists perform basic quality control of data. Here, we present BarQC, tool, which identifies corrects barcodes provides report on distribution each barcode UMI as well an estimation number cells Additionally, BarQC can be incorporated pipeline by constructing sorted BAM file tagged with sequence. Availability Implementation was implemented Python3, its source code freely available GitHub at https://github.com/mayflylab/barQC/ under MIT Licence. has been tested Linux server.

Language: Английский

Citations

0
Multiple developmental pathways in organisms with developmentally complex life cycles DOI Creative Commons
Giuseppe Fusco, Alessandro Minelli

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: May 14, 2025

One aspect under which an organism's life cycle can be considered complex is when the very same organism undertake, or obligatorily undertakes, multiple developmental pathways. Examples are organisms with alternation of generations, like most plants, reproductive and/or options, many marine invertebrates. With a broad taxonomic coverage across eukaryotes, we survey these developmentally cycles, presenting selected case studies to illustrate relationships between diverse pathways within for what concerns morphogenesis and gene expression. We highlight deep connections different types cycles show their relationship phenotypic plasticity, sexual dimorphism ecological adaptation. The collected materials organized concepts provide basis future investigations on disparity evolution tree life.

Language: Английский

Citations

0