Apoptosis is Increased in Cortical Neurons of Female Marfan Syndrome Mice DOI
Mitra Esfandiarei, Faizan Anwar,

Manogna Nuthi

et al.

Published: Jan. 1, 2024

Language: Английский

Apoptosis is increased in cortical neurons of female Marfan Syndrome mice DOI Creative Commons
Mitra Esfandiarei, Faizan Anwar,

Manogna Nuthi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Marfan Syndrome (MFS) is an autosomal dominant genetic disorder that affects connective tissue throughout the body due to mutations in FBN1 gene. Individuals with MFS display symptoms different organs, particularly vasculature, but mechanisms of this multi-system dysfunction are still under investigation. There a gap our understanding impact monogenic aberrations on brain. This study aims determine neurodegeneration, cortical brain male and female mice. Brain 6-month-old mice C1041G/+ mutation wildtype litter mates was collected stained for active caspase-3 (ac3), derived neurotrophic factor (BDNF), neuronal nuclei (NeuN) or TUNEL DAPI. Data revealed increased levels ac3 neurons within sensory motor areas compared sex- age-matched controls. We confirm apoptosis using staining same areas. also report BDNF These results indicate heightened susceptibility neurodegeneration mouse model MFS. Significance Statement The have more apoptotic mates.

Language: Английский

Citations

1
Apoptosis is Increased in Cortical Neurons of Female Marfan Syndrome Mice DOI
Mitra Esfandiarei, Faizan Anwar,

Manogna Nuthi

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0