Are oligodendrocytes bystanders or drivers of Parkinson’s disease pathology? DOI Creative Commons
Jorge Campos, Lena F. Burbulla, Sarah Jäkel

et al.

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(1), P. e3002977 - e3002977

Published: Jan. 8, 2025

The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative and movement disorder, is predominant degeneration dopaminergic neurons in substantia nigra, a part midbrain. Despite decades research, molecular mechanisms origin remain unknown. While was initially viewed as purely neuronal results from single-cell transcriptomics have suggested that oligodendrocytes may play an important role early stages Parkinson’s. Although these findings are high relevance, particularly to search for effective disease-modifying therapies, actual functional Parkinson’s remains highly speculative requires concerted scientific effort be better understood. This Unsolved Mystery discusses limited understanding PD, highlighting unresolved questions regarding changes oligodendroglia, myelin nigral neurons, impact toxic environment, aggregation alpha-synuclein within oligodendrocytes.

Language: Английский

Are oligodendrocytes bystanders or drivers of Parkinson’s disease pathology? DOI Creative Commons
Jorge Campos, Lena F. Burbulla, Sarah Jäkel

et al.

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(1), P. e3002977 - e3002977

Published: Jan. 8, 2025

The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative and movement disorder, is predominant degeneration dopaminergic neurons in substantia nigra, a part midbrain. Despite decades research, molecular mechanisms origin remain unknown. While was initially viewed as purely neuronal results from single-cell transcriptomics have suggested that oligodendrocytes may play an important role early stages Parkinson’s. Although these findings are high relevance, particularly to search for effective disease-modifying therapies, actual functional Parkinson’s remains highly speculative requires concerted scientific effort be better understood. This Unsolved Mystery discusses limited understanding PD, highlighting unresolved questions regarding changes oligodendroglia, myelin nigral neurons, impact toxic environment, aggregation alpha-synuclein within oligodendrocytes.

Language: Английский

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