PLoS Pathogens, Journal Year: 2025, Volume and Issue: 21(4), P. e1013090 - e1013090
Published: April 23, 2025
Viruses have evolved to efficiently navigate host cells deliver, express, and replicate their genetic material. Understanding the mechanisms underlying viral RNA localisation is paramount designing new antivirals. In this review, we discuss Influenza A Virus (IAV) as a model system highlight some of ways in which viruses can hijack endomembrane systems, well nuclear transporters, achieve correct transcripts. IAV exemplifies nuclear-replicating virus with complex highly regulated trafficking within cells. The subverts various vesicular transport systems altering normal cellular functions. begins during entry; after clathrin-mediated endocytosis, genome (vRNPs) released into cytosol fusion endosomal membrane, it subsequently imported nucleus via importin system. There, vRNPs engage most major subnuclear structures exploit chromatin, transcription machinery splicing apparatus efficient mRNA synthesis export. Subsequently, newly synthesised are rapidly exported from contact host’s recycling endosome network for plasma membrane. We critical remodelling entire system, particularly Rab11 endoplasmic reticulum. Lastly, replicated genomes come together bundles be inserted budding virions, current models being proposed evidence behind them. Despite advances understanding these processes, several knowledge gaps remain, regarding specific export unspliced transcripts, segment bundling.
Language: Английский