Spatial and network principles behind neural generation of locomotion DOI Creative Commons
Salif Komi,

August Winther,

Grace Houser

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

ABSTRACT Generation of locomotion is a fundamental function the spinal cord, yet underlying principles remain unclear. In particular, relationship between neuronal cell types, networks and has been difficult to establish 1, 2 . Here, we propose by which functions arise primarily from spatial features cord. First, suggest that distinct types with dissimilar length projection constitute an asymmetrical “Mexican hat” topology, i.e. local excitation surrounding inhibition, along rostro-caudal axis. Second, transversal segregation conveniently allows synapses form appropriate targets. We demonstrate these in model mouse where are constructed probabilistic sampling synaptic connections cell-specific patterns, gleaned literature 3, 4 The cell-type distributions derived single-cell RNA sequencing combined transcriptomics 5 find essential aspects recapitulated easily controlled, several experimental observations can now be explained mechanistically. Further, two main predicted: propagating bumps neural activity asymmetric projections wider inhibition. Besides linking structure function, our approach provides unifying framework for understanding motor across limbed undulatory species.

Language: Английский

Spatial and network principles behind neural generation of locomotion DOI Creative Commons
Salif Komi,

August Winther,

Grace Houser

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

ABSTRACT Generation of locomotion is a fundamental function the spinal cord, yet underlying principles remain unclear. In particular, relationship between neuronal cell types, networks and has been difficult to establish 1, 2 . Here, we propose by which functions arise primarily from spatial features cord. First, suggest that distinct types with dissimilar length projection constitute an asymmetrical “Mexican hat” topology, i.e. local excitation surrounding inhibition, along rostro-caudal axis. Second, transversal segregation conveniently allows synapses form appropriate targets. We demonstrate these in model mouse where are constructed probabilistic sampling synaptic connections cell-specific patterns, gleaned literature 3, 4 The cell-type distributions derived single-cell RNA sequencing combined transcriptomics 5 find essential aspects recapitulated easily controlled, several experimental observations can now be explained mechanistically. Further, two main predicted: propagating bumps neural activity asymmetric projections wider inhibition. Besides linking structure function, our approach provides unifying framework for understanding motor across limbed undulatory species.

Language: Английский

Citations

1