Cellular immune breadth of an Omicron-specific, self-amplifying monovalent mRNA vaccine booster for COVID-19 DOI Creative Commons
Durgesh Kumar, Kishor Gaikwad,

Rushank Gunnale

et al.

npj Vaccines, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 1, 2025

Selecting a booster vaccine strategy that generates cellular immune breadth is crucial for effectively recalling reservoirs upon infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. This post hoc analysis from multicentre, randomized phase 3 study (CTRI/2022/10/046475) compared the induced by self-replicating mRNA (samRNA) GEMCOVAC-OM, encoding Omicron B.1.1.529 Spike protein, adenovector ChAdOx1 nCoV-19, Wuhan variant when administered as booster. GEMCOVAC-OM elicited significant expansion of memory B-cells (MBCs) specific to B.1.1.529, nCoV-19. also more reactive XBB.1.5 and BA.2.86 proteins. Additionally, triggered higher frequencies Omicron-Spike-specific T-cells, including stem cell, central, effector subsets. In summary, while nCoV-19 showed some cross-reactivity, targeted response. offers broader, longer-lasting immunity, making it promising candidate future development global distribution.

Language: Английский

Cellular immune breadth of an Omicron-specific, self-amplifying monovalent mRNA vaccine booster for COVID-19 DOI Creative Commons
Durgesh Kumar, Kishor Gaikwad,

Rushank Gunnale

et al.

npj Vaccines, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 1, 2025

Selecting a booster vaccine strategy that generates cellular immune breadth is crucial for effectively recalling reservoirs upon infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. This post hoc analysis from multicentre, randomized phase 3 study (CTRI/2022/10/046475) compared the induced by self-replicating mRNA (samRNA) GEMCOVAC-OM, encoding Omicron B.1.1.529 Spike protein, adenovector ChAdOx1 nCoV-19, Wuhan variant when administered as booster. GEMCOVAC-OM elicited significant expansion of memory B-cells (MBCs) specific to B.1.1.529, nCoV-19. also more reactive XBB.1.5 and BA.2.86 proteins. Additionally, triggered higher frequencies Omicron-Spike-specific T-cells, including stem cell, central, effector subsets. In summary, while nCoV-19 showed some cross-reactivity, targeted response. offers broader, longer-lasting immunity, making it promising candidate future development global distribution.

Language: Английский

Citations

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