bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 16, 2024
Abstract Genome sequencing has revealed a tremendous diversity of transposable elements (TEs) in eukaryotes but there is little understanding the evolutionary processes responsible for TE diversity. Non-autonomous TEs have lost machinery necessary transposition and rely on closely related autonomous critical proteins. We studied two mathematical models regulation, one assuming that both tranposons their non-autonomous relatives operate under same regulatory logic, competing resources, self-attenuate while transposons continually increase, parasitizing relatives. implemented these stochastic simulations how relationships influence populations. found only outcrossing populations evolving with Parasitic regulation resulted stable maintenance TEs. tested our model predictions Caenorhabditis genomes by annotating focal families, LINEs SINE DNA transposon Mutator . broad variation - rapid mutational decay sequences allow to transpose. Together, results suggest individual families evolve according disparate rules are relevant early, acute stages invasion.
Language: Английский