A novel framework for assessing causal effect of microbiome on health: long-term antibiotic usage as an instrument

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 23, 2025

Assessing causality is undoubtedly one of the key questions in microbiome studies for upcoming years. Since randomized trials human subjects are often unethical or difficult to pursue, analytical methods derive causal effects from observational data deserve attention. As simple covariate adjustment not likely account all potential confounders, idea instrumental variable (IV) analysis worth exploiting. Here we propose a novel framework antibiotic regression (AB-IVR) estimating relationships between and various diseases. We rely on recent showing that treatment has cumulative long-term effect microbiome, resulting individuals with higher usage have more perturbed microbiome. apply AB-IVR method Estonian Biobank show role numerous diseases including migraine, depression irritable bowel syndrome. plethora sensitivity analyses identified robust ways further methodological developments.

Language: Английский

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Diverse landscape of genomic research within the Estonian Biobank

Human Molecular Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

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