Y and Mitochondrial Chromosomes in the Heterogeneous Stock Rat Population DOI Creative Commons
Faith Okamoto, Apurva S. Chitre, Thiago Missfeldt Sanches

et al.

G3 Genes Genomes Genetics, Journal Year: 2024, Volume and Issue: 14(11)

Published: Sept. 9, 2024

Abstract Genome-wide association studies typically evaluate the autosomes and sometimes X Chromosome, but seldom consider Y or mitochondrial (MT) Chromosomes. We genotyped MT Chromosomes in heterogeneous stock (HS) rats (Rattus norvegicus), an outbred population created from 8 inbred strains. identified distinct 4 among founders. However, only 2 types of each nonrecombinant chromosome were observed our modern HS rat (generations 81–97). Despite relatively large sample size, there virtually no significant associations for behavioral, physiological, metabolome, microbiome traits after correcting multiple comparisons. both strongly associated with expression a few genes located on those chromosomes, which provided positive control. Our results suggest that within are differences influence behavioral physiological traits. These do not address other ancestral appear rats, nor they effects may exist populations, species.

Language: Английский

Y and Mitochondrial Chromosomes in the Heterogeneous Stock Rat Population DOI Creative Commons
Faith Okamoto, Apurva S. Chitre, Thiago Missfeldt Sanches

et al.

G3 Genes Genomes Genetics, Journal Year: 2024, Volume and Issue: 14(11)

Published: Sept. 9, 2024

Abstract Genome-wide association studies typically evaluate the autosomes and sometimes X Chromosome, but seldom consider Y or mitochondrial (MT) Chromosomes. We genotyped MT Chromosomes in heterogeneous stock (HS) rats (Rattus norvegicus), an outbred population created from 8 inbred strains. identified distinct 4 among founders. However, only 2 types of each nonrecombinant chromosome were observed our modern HS rat (generations 81–97). Despite relatively large sample size, there virtually no significant associations for behavioral, physiological, metabolome, microbiome traits after correcting multiple comparisons. both strongly associated with expression a few genes located on those chromosomes, which provided positive control. Our results suggest that within are differences influence behavioral physiological traits. These do not address other ancestral appear rats, nor they effects may exist populations, species.

Language: Английский

Citations

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