Heterogeneous distribution of inhibitory inputs among motor units as a key mechanism for motor adaptations to pain DOI Creative Commons
François Hug,

François Dernoncourt,

Simon Avrillon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Abstract Pain significantly influences movement, yet the precise neural mechanisms underlying wide range of observed motor adaptations remain unclear. This study combined experimental data and in silico models to investigate contribution inhibitory neuromodulatory inputs unit behaviour during submaximal contractions performed presence pain. Specifically, we aimed unravel distribution pattern pool. Seventeen participants isometric knee extension tasks under three conditions: Control, (induced by injecting hypertonic saline into infra-patellar fat pad), Washout. We identified large samples units vastus lateralis (up 53/participant) from high-density electromyographic signals, which led key observations. First, while discharge rates decreased Pain, a substantial proportion (14.8-24.8%) did not show this decrease and, some cases, even exhibited an increase. Second, using complementary approaches showed that pain alter amplification prolongation effects persistent inward currents on discharge, providing evidence drive neurons remained unchanged. Third, significant reduction common Pain. To explore potential neurophysiological these results, simulated pools with varying patterns inputs. Our simulation supports hypothesis non-homogeneous inputs, independent size, as mechanism Significance statement challenges traditional view homogeneous inhibition noxious stimulation strongly contemporary theories propose across Although previous research has differential responses - others increased findings alone cannot distinguish between inhibition. By combining modelling, provide compelling is non-uniformly distributed units,

Language: Английский

Heterogeneous distribution of inhibitory inputs among motor units as a key mechanism for motor adaptations to pain DOI Creative Commons
François Hug,

François Dernoncourt,

Simon Avrillon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Abstract Pain significantly influences movement, yet the precise neural mechanisms underlying wide range of observed motor adaptations remain unclear. This study combined experimental data and in silico models to investigate contribution inhibitory neuromodulatory inputs unit behaviour during submaximal contractions performed presence pain. Specifically, we aimed unravel distribution pattern pool. Seventeen participants isometric knee extension tasks under three conditions: Control, (induced by injecting hypertonic saline into infra-patellar fat pad), Washout. We identified large samples units vastus lateralis (up 53/participant) from high-density electromyographic signals, which led key observations. First, while discharge rates decreased Pain, a substantial proportion (14.8-24.8%) did not show this decrease and, some cases, even exhibited an increase. Second, using complementary approaches showed that pain alter amplification prolongation effects persistent inward currents on discharge, providing evidence drive neurons remained unchanged. Third, significant reduction common Pain. To explore potential neurophysiological these results, simulated pools with varying patterns inputs. Our simulation supports hypothesis non-homogeneous inputs, independent size, as mechanism Significance statement challenges traditional view homogeneous inhibition noxious stimulation strongly contemporary theories propose across Although previous research has differential responses - others increased findings alone cannot distinguish between inhibition. By combining modelling, provide compelling is non-uniformly distributed units,

Language: Английский

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