Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis DOI Creative Commons
Amir Barzegar Behrooz,

Hamid Latifi-Navid,

Narges Zolfaghari

et al.

BJC Reports, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 24, 2025

Glioblastoma (GB), an aggressive brain malignancy with a poor prognosis of 1.5-2 years, rarely exhibits extracranial metastasis (ECM). However, metabolic reprogramming has emerged as key driver GB progression and invasiveness. This study presents rare case recurrent scalp metastasis, exploring how shifts enable cells to evade treatment adapt hostile environments, offering insights for developing innovative therapies. Tandem mass spectrometry (MS/MS) was employed analyze amino acid profiles in both the metastatic stages GB. Systems biology approaches were used uncover genetic alterations associated from recurrence metastasis. Our analysis revealed distinct utilization patterns patient molecular phenotype wild-type IDH-1&2, TERT mutation, non-mutated BRAF EGFR, non-methylated MGMT. During significant differences observed between blood cerebrospinal fluid (CSF) samples. Additionally, protein-protein interaction (PPI) identified genomic drivers potentially responsible transition Beyond established risk factors such craniotomy, biopsies, ventricular shunting, radiation therapy, our findings suggest that plays crucial role Targeting these could provide new avenues managing preventing GB, making this important focus future research.

Language: Английский

Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis DOI Creative Commons
Amir Barzegar Behrooz,

Hamid Latifi-Navid,

Narges Zolfaghari

et al.

BJC Reports, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 24, 2025

Glioblastoma (GB), an aggressive brain malignancy with a poor prognosis of 1.5-2 years, rarely exhibits extracranial metastasis (ECM). However, metabolic reprogramming has emerged as key driver GB progression and invasiveness. This study presents rare case recurrent scalp metastasis, exploring how shifts enable cells to evade treatment adapt hostile environments, offering insights for developing innovative therapies. Tandem mass spectrometry (MS/MS) was employed analyze amino acid profiles in both the metastatic stages GB. Systems biology approaches were used uncover genetic alterations associated from recurrence metastasis. Our analysis revealed distinct utilization patterns patient molecular phenotype wild-type IDH-1&2, TERT mutation, non-mutated BRAF EGFR, non-methylated MGMT. During significant differences observed between blood cerebrospinal fluid (CSF) samples. Additionally, protein-protein interaction (PPI) identified genomic drivers potentially responsible transition Beyond established risk factors such craniotomy, biopsies, ventricular shunting, radiation therapy, our findings suggest that plays crucial role Targeting these could provide new avenues managing preventing GB, making this important focus future research.

Language: Английский

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