Non‐Invasive Auricular Vagus Nerve Stimulation Decreases Heart Rate Variability Independent of Caloric Load DOI Creative Commons
Kristin Kaduk, A. Petrella, Sophie J. Müller

et al.

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(2)

Published: Feb. 1, 2025

ABSTRACT The vagus nerve is crucial in regulating physiological functions, including the cardiovascular system. While heart rate (HR) and its variability (HRV) may provide non‐invasive proxies of cardiac vagal activity, transcutaneous auricular stimulation (taVNS) has yielded mixed effects, with limited research on right branch stimulation. In a randomized crossover study 36 healthy participants, we investigated taVNS effects HR HRV indexed by SDRR, RMSSD, HF‐HRV, LF/HF ratio. To assess impact side (left vs. ear) indices interaction state, recorded electrocardiograms four sessions per person, covering three session phases: baseline, during (taVNS sham), post‐milkshake consumption First, found moderate evidence against affecting (BF 10 = 0.21). Second, decreased (multivariate p 0.004) independent strong for RMSSD 15.11) HF‐HRV 11.80). Third, taVNS‐induced changes were comparable across sides stronger than sham, indicating consistent side. We conclude that reduces as SDRR without altering HR, contradicting assumption se increases cardiovagal activity increased due to stimulating afferents. Instead, our results support role afferent activation arousal. Crucially, both can safely modulate system increasing risk bradycardia or causing adverse events offering new treatment possibilities.

Language: Английский

Toward a functional future for the cognitive neuroscience of human aging DOI Creative Commons

Zoya Mooraj,

Alireza Salami, Karen L. Campbell

et al.

Neuron, Journal Year: 2025, Volume and Issue: 113(1), P. 154 - 183

Published: Jan. 1, 2025

Language: Английский

Citations

1
Transcutaneous Auricular Vagus Nerve Stimulation Does Not Accelerate Fear Extinction: A Randomized, Sham‐Controlled Study DOI Open Access
Martina D’Agostini,

Lucas Vanden Bossche,

Andreas M. Burger

et al.

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(1)

Published: Jan. 1, 2025

ABSTRACT Transcutaneous auricular vagus nerve stimulation (taVNS) has been tested as a strategy to facilitate fear extinction learning based on the hypothesis that taVNS increases central noradrenergic activity. Four studies out of six found enhance especially at beginning extinction. Facilitatory effects were mainly observed in US expectancy, less fear‐potentiated startle (FPS), and not skin conductance response (SCR). Suboptimal parameters may explain reported mixed results. Also, variability selected conditioning paradigms statistical power impedes comparability between studies. This study sought further test whether accelerates indexed by FPS, SCR. Similar most previous studies, we employed differential paradigm. The left ear 79 healthy participants was stimulated with either sham (earlobe) or (cymba concha) during learning. To maximize beneficial taVNS, cymba concha administered continuously maximum level below pain threshold. Results pre‐registered frequentist exploratory Bayesian analyses indicate did accelerate any outcomes. null results commonly used does reliably optimize More research is needed if protocol determines efficacy optimizing

Language: Английский

Citations

1
Non‐Invasive Auricular Vagus Nerve Stimulation Decreases Heart Rate Variability Independent of Caloric Load DOI Creative Commons
Kristin Kaduk, A. Petrella, Sophie J. Müller

et al.

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(2)

Published: Feb. 1, 2025

ABSTRACT The vagus nerve is crucial in regulating physiological functions, including the cardiovascular system. While heart rate (HR) and its variability (HRV) may provide non‐invasive proxies of cardiac vagal activity, transcutaneous auricular stimulation (taVNS) has yielded mixed effects, with limited research on right branch stimulation. In a randomized crossover study 36 healthy participants, we investigated taVNS effects HR HRV indexed by SDRR, RMSSD, HF‐HRV, LF/HF ratio. To assess impact side (left vs. ear) indices interaction state, recorded electrocardiograms four sessions per person, covering three session phases: baseline, during (taVNS sham), post‐milkshake consumption First, found moderate evidence against affecting (BF 10 = 0.21). Second, decreased (multivariate p 0.004) independent strong for RMSSD 15.11) HF‐HRV 11.80). Third, taVNS‐induced changes were comparable across sides stronger than sham, indicating consistent side. We conclude that reduces as SDRR without altering HR, contradicting assumption se increases cardiovagal activity increased due to stimulating afferents. Instead, our results support role afferent activation arousal. Crucially, both can safely modulate system increasing risk bradycardia or causing adverse events offering new treatment possibilities.

Language: Английский

Citations

0