Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169161 - 169161
Published: April 1, 2025
Mitochondrial quality control is instrumental in regulating neuronal health and survival. The receptor-mediated clearance of damaged mitochondria by autophagy, known as mitophagy, plays a key role controlling mitochondrial homeostasis. Mutations genes that regulate mitophagy are causative for familial forms neurological disorders including Parkinson's disease (PD) Amyotrophic lateral sclerosis(ALS). PINK1/Parkin-dependent the best studied pathway, while more recent work has brought to light additional mechanisms operate either parallel or independent PINK1/Parkin mitophagy. Here, we discuss our current understanding operating neurons govern We also summarize progress links between mitophagic dysfunction neurodegeneration highlight potential therapeutic interventions maintain function.
Language: Английский