Mapping the GDF15 Arm of the Integrated Stress Response in Human Cells and Tissues DOI Creative Commons
Janell L.M. Smith, Kamaryn Tanner,

Jack Devine

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Abstract Mitochondrial stress activates the integrated response (ISR) and triggers cell-cell communication through secretion of metabokine growth differentiation factor 15 (GDF15). However, gene network underlying ISR remains poorly defined, particularly across metabolically diverse cellular states tissues. Using RNAseq data from fibroblasts subjected to metabolic perturbations, we develop an GDF15 index quantifying arm activation in human cells. Validation 44 postmortem tissues illustrates how this can be applied investigate tissue-specific age-related activation.

Language: Английский

Mapping the GDF15 Arm of the Integrated Stress Response in Human Cells and Tissues DOI Creative Commons
Janell L.M. Smith, Kamaryn Tanner,

Jack Devine

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Abstract Mitochondrial stress activates the integrated response (ISR) and triggers cell-cell communication through secretion of metabokine growth differentiation factor 15 (GDF15). However, gene network underlying ISR remains poorly defined, particularly across metabolically diverse cellular states tissues. Using RNAseq data from fibroblasts subjected to metabolic perturbations, we develop an GDF15 index quantifying arm activation in human cells. Validation 44 postmortem tissues illustrates how this can be applied investigate tissue-specific age-related activation.

Language: Английский

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