Gene Expression Changes as Biomarkers of Immunosenescence in Bulgarian Individuals of Active Age

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 721 - 721

Published: March 15, 2025

Background/Objectives: Immunosenescence implies innate and adaptive immunity dysfunction, which naturally occurs with aging. It is a complex multifactorial process can be triggered by either genetic changes, immune changes or both. Numerous research studies have shown that the of senescence goes alongside chronic activation. The purpose this study to analyze in expression genes associated responses order identify reliable biomarkers for Methods: For aim, 55 clinically healthy individuals active age (21–65 years) were distributed based on immunophenotyping two groups, without signs premature senescence. A gene analysis was subsequently made those differentially expressed presented interpreted. Results: Altogether, forty-eight (48) exhibited differential between most showed up-regulation (45) (fold change more than 2), only three down-regulated less −2). highest positive fold IL-1β (10.76), BCL6 (13.25) CCL4 (15.91), while negative documented IL23R (−3.10), IL5 (−2.66) PTGS2 (COX-2) (−2.15). Conclusions: Our results reveal immunosenescence positively inflammation, typical aging process. On other hand, we identified markers possible protective effects against oxidative stress tumorigenesis. These findings aid early diagnosis degenerative diseases subclinical phase, as well development strategies prevent processes

Language: Английский

Prostaglandins and the Cardiovascular System

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2025, Volume and Issue: 45(6), P. 841 - 844

Published: May 21, 2025

Language: Английский