The Anatomy of Context DOI Open Access
Rebecca D. Burwell

Hippocampus, Journal Year: 2024, Volume and Issue: 35(1)

Published: Dec. 25, 2024

ABSTRACT For most of my career, I focused on understanding how and where spatial context, the place things happen, is represented in brain. My interest this began early 1990's, during postdoctoral training with David Amaral, when we defined rodent homolog primate parahippocampal cortex, a region implicated processing contextual information. We parceled out caudal portion rat perirhinal cortex (PER) called it postrhinal (POR). In own lab at Brown University, continued to study anatomy PER, POR, entorhinal cortices. also characterize differentiate functions these regions, particularly newly POR redefined PER. Our electrophysiological behavioral evidence supports view function that aligns our anatomical evidence. Briefly, integrates object feature information from PER retrosplenial, posterior parietal, secondary visual cortices pulvinar uses represent specific environmental contexts, including arrangement objects features within each context. addition maintaining representation current plays an attentional role by continually monitoring context for changes updating occur. This accessible other regions cognitive processes, binding life events form episodic memories, guiding context‐relevant behavior, recognizing scenes contexts.

Language: Английский

Information transfer from spatial to social distance in rats: implications for the role of the posterior parietal cortex in spatial-social integration DOI Open Access
Taylor B. Wise, Victoria L. Templer, Rebecca D. Burwell

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

ABSTRACT Humans and other social animals can represent navigate complex networks of relationships in ways that are suggestive representation navigation space. There is some evidence cortical regions initially required for processing space have been adapted to include information. One candidate region supporting both spatial information the posterior parietal cortex (PPC). We examined hypothesis rats transfer or generalize distance across domains this phenomenon requires PPC. In a novel apparatus, learned discriminate two conspecifics positioned at different distances (near vs. far) goal-driven paradigm. Following learning, subjects were tested on probe trials which was replaced with (cagemate less familiar conspecific). The PPC chemogenetically inactivated during subset sessions. predicted that, control trials, would select whose matched previously distance. That is, if trained near distance, rat choose highly cagemate, far conspecific. Subjects based our Moreover, choice appropriate first session significantly higher than chance. This result suggests transferred contexts. Contrary predictions, inactivation did not impair transfer. Possible reasons discussed. To knowledge, study provide processed by shared cognitive mechanisms model.

Language: Английский

Citations

1
The Anatomy of Context DOI Open Access
Rebecca D. Burwell

Hippocampus, Journal Year: 2024, Volume and Issue: 35(1)

Published: Dec. 25, 2024

ABSTRACT For most of my career, I focused on understanding how and where spatial context, the place things happen, is represented in brain. My interest this began early 1990's, during postdoctoral training with David Amaral, when we defined rodent homolog primate parahippocampal cortex, a region implicated processing contextual information. We parceled out caudal portion rat perirhinal cortex (PER) called it postrhinal (POR). In own lab at Brown University, continued to study anatomy PER, POR, entorhinal cortices. also characterize differentiate functions these regions, particularly newly POR redefined PER. Our electrophysiological behavioral evidence supports view function that aligns our anatomical evidence. Briefly, integrates object feature information from PER retrosplenial, posterior parietal, secondary visual cortices pulvinar uses represent specific environmental contexts, including arrangement objects features within each context. addition maintaining representation current plays an attentional role by continually monitoring context for changes updating occur. This accessible other regions cognitive processes, binding life events form episodic memories, guiding context‐relevant behavior, recognizing scenes contexts.

Language: Английский

Citations

0