Dopaminergic encoding of future defensive actions in the mouse nucleus accumbens DOI Creative Commons

Austen A Fisher,

L Sofia Gonzalez,

Zoe Cappel

et al.

PNAS Nexus, Journal Year: 2025, Volume and Issue: 4(5)

Published: April 29, 2025

Dopamine release in the nucleus accumbens (NAc) plays a critical role motivation to perform actions that promote survival. However, NAc dopamine response innately threatening visual stimuli, such as predators descending from above, and innate behaviors they has not been fully characterized. Using genetically encoded sensor dLight1, we investigated looming threat-evoked lateral (LNAc) medial shell (NAcS) regions freely moving mice during performance of stimulus assay. We found related threat perception NAcS, but LNAc, predicts timing vigor future defensive action, yet released action itself does not. Optogenetic inhibition dopaminergic terminals NAcS at onset prevented escape, confirming for ventral striatal promoting threat-related behaviors.

Language: Английский

Examining the role of the photopigment melanopsin in the striatal dopamine response to light DOI Creative Commons

L Sofia Gonzalez,

Austen A Fisher,

Kassidy E Grover

et al.

Frontiers in Systems Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 2, 2025

The mesolimbic dopamine system is a set of subcortical brain circuits that plays key role in reward processing, reinforcement, associative learning, and behavioral responses to salient environmental events. In our previous studies the dopaminergic response visual stimuli, we observed release lateral nucleus accumbens (LNAc) mice encoded information about rate magnitude rapid luminance changes from darkness. Light-evoked were rate-dependent, robust time testing or stimulus novelty, required phototransduction by rod cone opsins. However, it unknown if these also involve non-visual opsins, such as melanopsin, primary photopigment expressed intrinsically photosensitive retinal ganglion cells (ipRGCs). current study, evaluated melanopsin light LNAc using genetically sensor dLight1 fiber photometry. By measuring light-evoked across broad irradiance wavelength range constitutive (Opn4) knockout mice, able provide new insights into ability opsins regulate stimuli.

Language: Английский

Citations

0
Dopaminergic encoding of future defensive actions in the mouse nucleus accumbens DOI Creative Commons

Austen A Fisher,

L Sofia Gonzalez,

Zoe Cappel

et al.

PNAS Nexus, Journal Year: 2025, Volume and Issue: 4(5)

Published: April 29, 2025

Dopamine release in the nucleus accumbens (NAc) plays a critical role motivation to perform actions that promote survival. However, NAc dopamine response innately threatening visual stimuli, such as predators descending from above, and innate behaviors they has not been fully characterized. Using genetically encoded sensor dLight1, we investigated looming threat-evoked lateral (LNAc) medial shell (NAcS) regions freely moving mice during performance of stimulus assay. We found related threat perception NAcS, but LNAc, predicts timing vigor future defensive action, yet released action itself does not. Optogenetic inhibition dopaminergic terminals NAcS at onset prevented escape, confirming for ventral striatal promoting threat-related behaviors.

Language: Английский

Citations

0