Examining the role of the photopigment melanopsin in the striatal dopamine response to light
L Sofia Gonzalez,
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Austen A Fisher,
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Kassidy E Grover
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et al.
Frontiers in Systems Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: April 2, 2025
The
mesolimbic
dopamine
system
is
a
set
of
subcortical
brain
circuits
that
plays
key
role
in
reward
processing,
reinforcement,
associative
learning,
and
behavioral
responses
to
salient
environmental
events.
In
our
previous
studies
the
dopaminergic
response
visual
stimuli,
we
observed
release
lateral
nucleus
accumbens
(LNAc)
mice
encoded
information
about
rate
magnitude
rapid
luminance
changes
from
darkness.
Light-evoked
were
rate-dependent,
robust
time
testing
or
stimulus
novelty,
required
phototransduction
by
rod
cone
opsins.
However,
it
unknown
if
these
also
involve
non-visual
opsins,
such
as
melanopsin,
primary
photopigment
expressed
intrinsically
photosensitive
retinal
ganglion
cells
(ipRGCs).
current
study,
evaluated
melanopsin
light
LNAc
using
genetically
sensor
dLight1
fiber
photometry.
By
measuring
light-evoked
across
broad
irradiance
wavelength
range
constitutive
(Opn4)
knockout
mice,
able
provide
new
insights
into
ability
opsins
regulate
stimuli.
Language: Английский
Dopaminergic encoding of future defensive actions in the mouse nucleus accumbens
Austen A Fisher,
No information about this author
L Sofia Gonzalez,
No information about this author
Zoe Cappel
No information about this author
et al.
PNAS Nexus,
Journal Year:
2025,
Volume and Issue:
4(5)
Published: April 29, 2025
Dopamine
release
in
the
nucleus
accumbens
(NAc)
plays
a
critical
role
motivation
to
perform
actions
that
promote
survival.
However,
NAc
dopamine
response
innately
threatening
visual
stimuli,
such
as
predators
descending
from
above,
and
innate
behaviors
they
has
not
been
fully
characterized.
Using
genetically
encoded
sensor
dLight1,
we
investigated
looming
threat-evoked
lateral
(LNAc)
medial
shell
(NAcS)
regions
freely
moving
mice
during
performance
of
stimulus
assay.
We
found
related
threat
perception
NAcS,
but
LNAc,
predicts
timing
vigor
future
defensive
action,
yet
released
action
itself
does
not.
Optogenetic
inhibition
dopaminergic
terminals
NAcS
at
onset
prevented
escape,
confirming
for
ventral
striatal
promoting
threat-related
behaviors.
Language: Английский