Lepidopteran scale cells derive from sensory organ precursors through a canonical lineage DOI Creative Commons
Ling S. Loh, Kyle A. DeMarr, Christa Heryanto

et al.

Development, Journal Year: 2025, Volume and Issue: 152(5)

Published: March 1, 2025

The success of butterflies and moths is tightly linked to the origin scales within group. A long-standing hypothesis postulates that are homologous well-described mechanosensory bristles found in fruit fly Drosophila melanogaster, as both derive from an epithelial precursor. Previous histological candidate gene approaches identified parallels genes involved scale bristle development. Here, we provide developmental transcriptomic evidence differentiation lepidopteran derives sensory organ precursor (SOP). Live imaging pupae shows SOP cells undergo two asymmetric divisions first abrogate neurogenic lineage, then lead a differentiated its associated socket cell. Single-nucleus RNA sequencing using early pupal wings revealed differential expression patterns mirror development, suggesting shared program. Additionally, recovered newly gene, transcription factor pdm3, proper butterfly wing scales. Altogether, these data open up avenues for understanding type specification illustrate how single-cell transcriptomics powerful platform evolution cell types.

Language: Английский

Lepidopteran scale cells derive from sensory organ precursors through a canonical lineage DOI Creative Commons
Ling S. Loh, Kyle A. DeMarr, Christa Heryanto

et al.

Development, Journal Year: 2025, Volume and Issue: 152(5)

Published: March 1, 2025

The success of butterflies and moths is tightly linked to the origin scales within group. A long-standing hypothesis postulates that are homologous well-described mechanosensory bristles found in fruit fly Drosophila melanogaster, as both derive from an epithelial precursor. Previous histological candidate gene approaches identified parallels genes involved scale bristle development. Here, we provide developmental transcriptomic evidence differentiation lepidopteran derives sensory organ precursor (SOP). Live imaging pupae shows SOP cells undergo two asymmetric divisions first abrogate neurogenic lineage, then lead a differentiated its associated socket cell. Single-nucleus RNA sequencing using early pupal wings revealed differential expression patterns mirror development, suggesting shared program. Additionally, recovered newly gene, transcription factor pdm3, proper butterfly wing scales. Altogether, these data open up avenues for understanding type specification illustrate how single-cell transcriptomics powerful platform evolution cell types.

Language: Английский

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