Modelling orexinergic system in ageing in the African turquoise killifish

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 14, 2025

Abstract The orexinergic system is anatomically and functionally conserved in almost all vertebrates, the role healthy ageing age-associated diseases has been studied mammals. Here, we review main findings on age-related regulation of mammals, including human patients highlights how fish Nothobranchius furzeri serves as an exceptional model to spearhead research unravel intricate mechanisms underlying during ageing. brain this teleost characterized by presence neurodegenerative processes similar those associated with pathologies rather than We present in-depth summary discussion groundbreaking advances understanding neuroanatomical organization system, its pivotal mammalian models, profound involvement diseases.

Language: Английский

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This key protein could be responsible for brain ageing

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

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