Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation DOI Creative Commons
James B. Isbister, András Ecker, Christoph Pokorny

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 17, 2023

Summary Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo . Large-scale, biophysically detailed models offer a tool can complement laboratory approaches. We present model comprising eight somatosensory cortex subregions, 4.2 million morphological electrically-detailed neurons, 13.2 billion local mid-range synapses. In silico tools enabled reproduction extension of experiments under single parameterization, providing strong validation. The reproduced millisecond-precise stimulus-responses, stimulus-encoding targeted optogenetic activation, selective propagation stimulus-evoked activity downstream areas. model’s direct correspondence with biology generated predictions about how multiscale organization shapes activity; for example, cortical is shaped by high-dimensional connectivity motifs connectivity, spatial targeting rules inhibitory subpopulations. latter was facilitated using rewired connectome included specific observed different neuron types electron microscopy. also predicted the role interneuron layers stimulus encoding. Simulation large subvolume made available enable further community-driven improvement, validation investigation.

Language: Английский

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation DOI Creative Commons
James B. Isbister, András Ecker, Christoph Pokorny

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 17, 2023

Summary Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo . Large-scale, biophysically detailed models offer a tool can complement laboratory approaches. We present model comprising eight somatosensory cortex subregions, 4.2 million morphological electrically-detailed neurons, 13.2 billion local mid-range synapses. In silico tools enabled reproduction extension of experiments under single parameterization, providing strong validation. The reproduced millisecond-precise stimulus-responses, stimulus-encoding targeted optogenetic activation, selective propagation stimulus-evoked activity downstream areas. model’s direct correspondence with biology generated predictions about how multiscale organization shapes activity; for example, cortical is shaped by high-dimensional connectivity motifs connectivity, spatial targeting rules inhibitory subpopulations. latter was facilitated using rewired connectome included specific observed different neuron types electron microscopy. also predicted the role interneuron layers stimulus encoding. Simulation large subvolume made available enable further community-driven improvement, validation investigation.

Language: Английский

Citations

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